AUTHOR=Mata-Rocha Minerva , Rangel-López Angelica , Jimenez-Hernandez Elva , Nuñez-Enríquez Juan Carlos , Morales-Castillo Blanca Angélica , Sánchez-Escobar Norberto , Sepúlveda-Robles Omar Alejandro , Bravata-Alcántara Juan Carlos , Nájera-Cortés Alan Steve , Pérez-Saldivar María Luisa , Flores-Lujano Janet , Duarte-Rodríguez David Aldebarán , Oviedo de Anda Norma Angélica , Romero Tlalolini Maria de los Angeles , Alaez Verson Carmen , Martín-Trejo Jorge Alfonso , Muñoz Medina Jose Esteban , Gonzalez-Bonilla Cesar Raul , Hernandez Cueto Maria de los Angeles , Bekker-Méndez VC. , Jiménez-Morales Silvia , Medina-Sansón Aurora , Amador-Sánchez Raquel , Peñaloza-González José Gabriel , Torres-Nava José Refugio , Espinosa-Elizondo Rosa Martha , Cortés-Herrera Beatriz , Flores-Villegas Luz Victoria , Merino-Pasaye Laura Elizabeth , Gutierrez-Rivera Maria de Lourdes , Velazquez-Aviña Martha Margarita , Santillan-Juarez Jessica Denisse , Gurrola-Silva Alma , Hernández Echáurregui Gabriela Alicia , Hidalgo-Miranda Alfredo , Arellano Galindo José , Rosas-Vargas Haydeé , Mejía-Aranguré Juan Manuel 

TITLE=Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.837656

DOI=10.3389/fped.2022.837656

ISSN=2296-2360

ABSTRACT=<p><italic>ETV6::RUNX1</italic> is a genetic rearrangement of good prognosis in children with acute lymphoblastic leukemia (ALL). In Mexico, its prevalence is low in comparison with Caucasian populations. We developed a novel TaqMan one-step RT-qPCR approach to assess the prevalence of four genetic rearrangements in a cohort of Hispanic children with ALL from Mexico City. The prevalence of common fusion gene transcripts was as follows: <italic>TCF3::PBX1</italic> 7.7%; <italic>BCR::ABL1p</italic><sup>190</sup> 3.3%; and <italic>KMT2A::AFF1</italic> 2.8%, and <italic>ETV6::RUNX1</italic>was observed with low prevalence (10.5%) in comparison to that reported for developed countries. This is consistent with previous findings on Mexican children with ALL and similar to those reported on children from Hispanic populations. The confirmation of a low prevalence of <italic>ETV6::RUNX1</italic> in children of a Hispanic origin represents an advancement in the description of genetic factors of ALL in these populations.</p>