AUTHOR=Yang Rong , Ai Yuan , Liu Chuan , Lu Xiaoxi 

TITLE=Aggressive Natural Killer Cell Leukemia in an Adolescent Patient: A Case Report and Literature Review

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.829927

DOI=10.3389/fped.2022.829927

ISSN=2296-2360

ABSTRACT=Aggressive natural killer cell leukemia (ANKL) is a rare malignant tumor, especially uncommon in children. ANKL has very aggressive clinical course and bad prognosis and is usually caused by Epstein-Barr virus infection. Here we report an ANKL in adolescent whose clinical presentation was highly aggressive and response to L-asparaginase containing chemotherapy was very bad. When an hemophagocytic lymphohistiocytosis patient is complicated with liver dysfunction and disseminated intravascular coagulation, diagnosis of ANKL should be considered. Early-onset Flow cytometry of peripheral blood and bone marrow help make the diagnosis.