AUTHOR=Edel Gabriëla G. , Schaaf Gerben , Wijnen Rene M. H. , Tibboel Dick , Kardon Gabrielle , Rottier Robbert J. 

TITLE=Cellular Origin(s) of Congenital Diaphragmatic Hernia

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.804496

DOI=10.3389/fped.2021.804496

ISSN=2296-2360

ABSTRACT=<p>Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.</p>