AUTHOR=Bonilla Gonzalez Carolina , Hincapié Echeverría Marcela , Plazas Pachón Rocio , Mora Umaña Paola , Diaz Gómez Berlly Lucia , Gualdron Barreto Nathalie 

TITLE=Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.780258

DOI=10.3389/fped.2021.780258

ISSN=2296-2360

ABSTRACT=<p><bold>Background:</bold> We describe the first pediatric case of a 10-month-old boy with MIS-C who developed fulminant acute liver failure with associated giant cell transformation and a fatal outcome, after ruling out other infectious, metabolic, genetic, and autoimmune causes of liver failure following the usual algorithms for approaching the etiology. Although the patient received the main treatment strategies for liver failure, he had a fatal outcome. A clinical autopsy was considered as part of the diagnostic approach, which showed evidence of giant cell transformation.</p>