AUTHOR=Josyabhatla Rohit , Kamdar Ankur A. , Armbrister Shabba A. , Daniel Rhea , Boukas Konstantinos , Smith Keely G. , Van Arsdall Melissa R. , Kakarala Kokila , Flores Anthony R. , Wanger Audrey , Liu Yuying , Rhoads Jon Marc TITLE=Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis JOURNAL=Frontiers in Pediatrics VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.748368 DOI=10.3389/fped.2021.748368 ISSN=2296-2360 ABSTRACT=

Historically, children evaluated for vomiting and diarrhea secondary to viral enteritis have symptoms lasting 2–4 days and respond to supportive care, including oral rehydration and anti-emetics if required. Recently, within a 14-day timespan, we encountered three children with severe diarrhea who rapidly became dehydrated and went into hypotensive shock. Although SARS-CoV-2 molecular tests were negative by nasopharyngeal swab, all were later found to have MIS-C. This small case series underscores features reported in previous larger studies and emphasizes the rapid clinical evolution of this condition. We highlight the importance of early recognition of cardinal laboratory findings characteristic of MIS-C (i.e., lymphopenia, markedly elevated acute phase reactants, and hypoalbuminemia). We also show serologic evidence that the pathophysiological mechanism of SARS-CoV-2 related diarrhea may differ from other causes of dehydrating vomiting and diarrhea, with no serologic evidence of villus cell injury.