Simone Sforza
Antonio Andrea Grosso
Lorenzo Masieri
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- 1Department of Pediatric Urology, Meyer Children Hospital, University of Florence, Florence, Italy
- 2Unit of Oncologic Minimally-Invasive Urology and Andrology, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, Florence, Italy
A Commentary on
Early Robotic-Assisted Laparoscopic Pyeloplasty for Infants Under 3 Months With Severe Ureteropelvic Junction Obstruction
by Li, P., Zhou, H., Cao, H., Guo, T., Zhu, W., Zhao, Y., et al. (2021). Front. Pediatr. 9:590865. doi: 10.3389/fped.2021.590865
Dear Prof. Arjan Te Pas,
Dear Dr. Miguel Alfedo Castellan,
We read the recently published article “Early Robotic-Assisted Laparoscopic Pyeloplasty for Infants Under 3 Months With Severe Ureteropelvic Junction Obstruction” with great interest (1). In this study, the authors performed a retrospective study of nine infants under 3 months submitted to robotic-assisted laparoscopic pyeloplasty (RALP) at their institution showing acceptable peri- and postoperative outcomes, including no major complication, a significant decrease in renal pelvis diameter, and improved renal function at 6- and 12-month follow-up.
The use of minimally invasive approach, and in particular the robotic one, to treat benign conditions in the pediatric urology field has tremendously expanded over the last few years with increasing consistent evidence showing comparable successful rate to the open treatment (2, 3) while offering decreased surgical morbidity and better cosmetic result (4). Moreover, as witnessed by several investigations, the indications for robotic correction of ureteropelvic junction obstruction (UPJO) has widened and comprised smaller (<15 kg) and younger (<1 year) infants (5, 6).
In this light, the present study seems to pose a little further cornerstone in the process of expansion of the robotic-assistance in this field. However, some key points need to be clarified. In particular, the authors reported a median operative time (OT) of 109.5 (±10.4) min, a length of hospitalization of 5.57 (±0.73) days, and an overall complication rate of 22% in their series. These outcomes seem to be high as compared with other minimally invasive surgical alternatives, in particular mini-laparoscopic.
Mini-laparoscopic pyeloplasty, indeed, has shown an optimal success rate among several studies, demonstrating a shorter OT and a lower complication rate (7, 8) as compared to the outcomes reported in the present study. Moreover, the mini-laparoscopic approach employs less invasive working ports than the robotic one (3 and 5 vs. 8 mm), translating into better scar acceptance and cosmetic results, which are key outcomes in this specific set of patients and pathologies.
Surprisingly, the authors did not qualitatively assess the cosmetic results in their series, which would have increased the value of the paper.
In addition, other surgical techniques needed to be mentioned since they have been investigated in a similar setting with favorable outcomes and in particular one-trocar-assisted pyeloplasty (OTAP) and open pyeloplasty via mini-flank incision (9, 10). Which are the patient-related benefits provided by RALP over these approaches?
On the contrary, as brilliantly discussed by the authors in their paper, RALP has the undoubted advantage of being an easier and reproducible procedure compared to the laparoscopic one, thus leading to a faster learning process; meanwhile, mini-laparoscopic pyeloplasty is burdened by a steep learning curve and thus demanding for highly skilled operators.
To conclude, the management of UPJO in the pediatric urology field is progressively changing, and the latest minimally invasive procedures are replacing the open strategy as the gold standard treatment. However, although RALP has shown enthusiastic results even in the setting of very small and young children, its adoption among infants <3 months has still to be carefully selected since faster surgeries with objectively assessed cosmetic results have been outlined in several papers without compromising the peri- and postoperative outcomes. Further studies with an adequate sample size and, hopefully, in a randomized setting are warranted to draw definitive conclusions.
Author Contributions
SS, AG, and LM conceived the original idea. SS and AG reviewed the final paper. All authors contributed to the final manuscript.
Funding
Aurora Biofarma S.R.L. that it is going to pay the publication fees.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1. Li P, Zhou H, Cao H, Guo T, Zhu W, Zhao Y, et al. Early robotic-assisted laparoscopic pyeloplasty for infants under 3 months with severe ureteropelvic junction obstruction. Front Pediatr. (2021) 9:590865. doi: 10.3389/fped.2021.590865
2. Masieri L, Sforza S, Grosso AA, Valastro F, Tellini R, Cini C, et al. Robot-assisted laparoscopic pyeloplasty in children: a systematic review. Minerva Urol Nefrol. (2020) 72:673–90. doi: 10.23736/S0393-2249.20.03854-0
3. Dangle PP, Kearns J, Anderson B, Gundeti MS. Outcomes of infants undergoing robot-assisted laparoscopic pyeloplasty compared to open repair. J Urol. (2013) 190:2221–7. doi: 10.1016/j.juro.2013.07.063
4. Wang MK, Li Y, Selekman RE, Gaither T, Arnhym A, Baskin LS. Scar acceptance after pediatric urologic surgery. J Pediatr Urol. (2018) 14:175.e1–6. doi: 10.1016/j.jpurol.2017.11.018
5. Masieri L, Sforza S, Grosso AA, Cini C, Viola L, Tellini R, et al. Does the body weight influence the outcome in children treated with robotic pyeloplasty? J Pediatr Urol. (2020) 16:109.e1–6. doi: 10.1016/j.jpurol.2019.10.023
6. Kawal T, Srinivasan AK, Shrivastava D, Chu DI, Van Batavia J, Weiss D, et al. Pediatric robotic-assisted laparoscopic pyeloplasty: does age matter? J Pediatr Urol. (2018) 14:540.e1–6. doi: 10.1016/j.jpurol.2018.04.023
7. Zhou H, Liu X, Xie H, Ma L, Zhou X, Tao T, et al. Early experience of using transumbilical multi-stab laparoscopic pyeloplasty for infants younger than 3 months. J Pediatr Urol. (2014) 10:854–8. doi: 10.1016/j.jpurol.2013.12.025
8. Ludwikowski BM, Botländer M, González R. The BULT method for pediatric minilaparoscopic pyeloplasty in infants: technique and results. Front Pediatr. (2016) 4:54. doi: 10.3389/fped.2016.00054
9. Lima M, Ruggeri G, Messina P, Tursini S, Destro F, Mogiatti M. One-trocar-assisted pyeloplasty in children: an 8-year single institution experience. Eur J Pediatr Surg. (2015) 25:262–8. doi: 10.1055/s-0034-1372459
Keywords: UPJO, pediatric, pyeloplasty, minimally invasive surgery, robot
Citation: Sforza S, Grosso AA and Masieri L (2021) Commentary: Early Robotic-Assisted Laparoscopic Pyeloplasty for Infants Under 3 Months With Severe Ureteropelvic Junction Obstruction. Front. Pediatr. 9:724219. doi: 10.3389/fped.2021.724219
Received: 12 June 2021; Accepted: 02 July 2021;
Published: 10 August 2021.
Edited by:
Lisandro Ariel Piaggio, Universidad Nacional del Sur, ArgentinaReviewed by:
Matthieu Peycelon, Indiana University, United StatesJuan Manuel Moldes, Italian Hospital of Buenos Aires, Argentina
Santiago Vallasciani, Sidra Medicine, Qatar
Mohan S. Gundeti, University of Chicago, United States
Copyright © 2021 Sforza, Grosso and Masieri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Simone Sforza, c2ltb25lLnNmb3J6YTE5ODhAZ21haWwuY29t
†These authors have contributed equally to this work