AUTHOR=Kumar Vijay , Angurana Suresh Kumar , Baranwal Arun Kumar , Nallasamy Karthi 

TITLE=Nasotracheal vs. Orotracheal Intubation and Post-extubation Airway Obstruction in Critically Ill Children: An Open-Label Randomized Controlled Trial

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.713516

DOI=10.3389/fped.2021.713516

ISSN=2296-2360

ABSTRACT=<p><bold>Background:</bold> The data on long-term nasotracheal intubation among mechanically ventilated critically ill children is limited. The purpose of this study was to compare the rate of post-extubation airway obstruction (PEAO) with nasotracheal and orotracheal intubation.</p><p><bold>Methods:</bold> This open-label randomized controlled trial was conducted in PICU of a tertiary care and teaching hospital in North India from January-December 2020 involving intubated children aged 3 months−12 years. After written informed consent, children were randomized into nasotracheal and orotracheal intubation groups. Post-extubation, modified Westley's croup score (mWCS) was used at 10-timepoints (0-min, 30 min, 1, 2, 3, 6, 12, 24, 36, and 48-h after extubation) to monitor for PEAO. The primary outcome was the rate of PEAO; and secondary outcomes were time taken for intubation, number of intubation attempts, complications during intubation, unplanned extubation, repeated intubations, tube malposition/displacement, endotracheal tube blockade, ventilator associated pneumonia, skin trauma, extubation failure/re-intubation, duration of PICU stay, and mortality.</p><p><bold>Results:</bold> Seventy children were randomized into nasotracheal (<italic>n</italic> = 30) and orotracheal (<italic>n</italic> = 40) groups. Both the groups were similar in baseline characteristics. The rate of PEAO was similar between nasotracheal and orotracheal groups (10 vs. 20%, <italic>p</italic> = 0.14). The maximum mWCS and mWCS at 10-timepoints were similar in two groups. The time taken for intubation was significantly longer (85 vs. 48 s, <italic>p</italic> &lt; 0.001) in nasotracheal group, whereas other secondary outcomes were similar in two groups.</p><p><bold>Conclusion:</bold> The rate of PEAO was not different between nasotracheal and orotracheal groups.</p><p><bold>Clinical Trial Registration:</bold><ext-link ext-link-type="uri" xlink:href="http://ctri.nic.in" xmlns:xlink="http://www.w3.org/1999/xlink">http://ctri.nic.in</ext-link>, Identifier: CTRI/2020/01/022988.</p>