AUTHOR=Ramachandran Prasanna Venkatesh , Healy C. Mary , Lambert Elton M. , Guerra Deyanara , Curry Choladda V. , Vogel Tiphanie P. 

TITLE=Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.674317

DOI=10.3389/fped.2021.674317

ISSN=2296-2360

ABSTRACT=<p>Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophilia and highly elevated IgE levels. Laboratory and histopathologic evaluation revealed an unlikely diagnosis of Kimura Disease. We discuss the differential diagnosis of a neck mass with prominent eosinophils on histology, and review support for T-helper type 2 (Th2) cell activation and hyper-IgE in Kimura Disease.</p>