AUTHOR=Chen Yanwei , Shen Xi 

TITLE=Compensatory Changes in the Anterior Segment and Vascular System of the Eye in Myopic Children After Orthokeratology

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.663644

DOI=10.3389/fped.2021.663644

ISSN=2296-2360

ABSTRACT=<p><bold>Purpose:</bold> To analyze changes in the anterior segment, retinal vessel density, and choroidal thickness (ChT) after orthokeratology (Ortho-K).</p><p><bold>Methods:</bold> Myopic children were enrolled from Ruijin Hospital, Shanghai, China. Ortho-K lenses and single-vision spectacles were fitted for myopia correction. Ocular measurements were taken at baseline and 6 months, including axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), white to white (WTW), ChT, macular vessel density (MVD), and optic disc vessel density (OVD).</p><p><bold>Results:</bold> Seventy-six patients were enrolled in this study, including 40 in the Ortho-K group and 36 in the control group. At baseline, no parameters between the two groups were statistically different. After 6 months, changes in CCT and ACD decreased in the Ortho-K group compared with those in the control group (<italic>p</italic> &lt; 0.05); LT and ChT in the Ortho-K group were thicker than those in the control group (<italic>p</italic> &lt; 0.05), while there was no difference in MVD and OVD compared with those in the control group (<italic>p</italic> &gt; 0.05). There were moderate positive correlations between ChT and LT and between ChT and OVD in the Ortho-K group (<italic>p</italic> &lt; 0.05).</p><p><bold>Conclusion:</bold> The changes in the anterior and posterior segments of the eye after Ortho-K lens wearing suggest that the human eye has a powerful compensatory effect on the imposed defocus.</p>