AUTHOR=Sieber Justyna , Renner Sabine , Lakatos-Krepcik Andrea , Szépfalusi Zsolt TITLE=Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years JOURNAL=Frontiers in Pediatrics VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.663228 DOI=10.3389/fped.2021.663228 ISSN=2296-2360 ABSTRACT=

Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application.