AUTHOR=Sieber Justyna , Renner Sabine , Lakatos-Krepcik Andrea , Szépfalusi Zsolt 

TITLE=Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.663228

DOI=10.3389/fped.2021.663228

ISSN=2296-2360

ABSTRACT=Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the successful desensitization of a 15-year-old cystic fibrosis patient by rush intravenous colomycin application over 4 hours, followed by 14-days intravenous treatment and finally a switch to a 10 year lasting colomycin inhalation treatment. The mechanism of drug tolerance is largely speculative; however long-term maintenance of it seems achievable by continuous local drug application.