AUTHOR=Zhou Ran , Zheng You-Ning , Zhang Xin-Ying , Cheng Ya-Ying 

TITLE=A Meta-Analysis of the Risk Factors of Persistent Pulmonary Hypertension in Newborns

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.659137

DOI=10.3389/fped.2021.659137

ISSN=2296-2360

ABSTRACT=<p><bold>Objective:</bold> To determine the risk factors of persistent pulmonary hypertension of the newborn using a meta-analysis method and provide a reference for its clinical prevention and treatment.</p><p><bold>Methods:</bold> A meta-analysis was performed by searching the PubMed, Embase, Cochrane Library, China Biology Medicine Disc, Wanfang, and Chinese VIP journal databases, as well as the China National Knowledge Infrastructure.</p><p><bold>Results:</bold> A total of 22 references were included in the meta-analysis; the cumulative medical records comprised 7,937 cases, and 2,613,072 control cases were included. A total of 12 related risk factors were included (7 were associated with pregnant women and 5 were associated with newborns).</p><p><bold>Conclusion:</bold> Among the 12 associated risk factors included, the three most important and their combined odds ratio values and 95% CI were as follows: (1) pregnant women smoking, 4.85 (1.98–11.9) during pregnancy; (2) gestational weeks &lt;37, 4.34 (1.64–11.5); (3) perinatal asphyxia, 3.9 (2.87–5.31).</p>