Han-Pi Chang1,2
Ming-Chou Chiang- 1Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
- 2Division of Pediatric Critical Care Medicine, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
- 3Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
Background: Neonatal splenic rupture/hemorrhage (SRH), an extremely rare and potentially fatal presentation, can spontaneously resolve without surgical treatment; However, treatment approaches remain controversial. The present study aimed to describe and analyze the clinical features and therapies of neonatal SRH and therapeutic approaches.
Methods: We present the cases of two patients and review another 37 cases reported in English-literature. The literature search included all articles published in PUBMED from inception between January 1968 and December 2019. Demographic data, precipitating factors, clinical characteristics including presenting symptoms and signs, presenting time, age at SRH presentation, imaging findings, as well as treatments and outcomes were analyzed.
Results: In addition to the two cases treated at our hospital, 37 neonates with SRH were reported during the study period. The rate of full-term neonates was 72% (28/39). The cause was idiopathic in most cases, and congenital coagulation disorders were underlying causes in 13% (5/39) of the cases. The most common presenting symptom and sign of neonatal SRH were pallor or anemia, followed by abdominal discoloration/distension. Additionally, 18% (7/39) of the cases presented with scrotal hematoma or swelling. The age at SRH presentation ranged between 3 h and 5 days of age. Abdominal ultrasonography or computed tomography was used as the diagnostic tool. Twenty-seven cases (69%) received surgical management. The prognosis was comparable between the neonates treated with splenectomy and those treated with non-surgical approaches. The mortality rate was 18% (7/39) in the study cohort. SRH presentation at ≤12 h of age was associated with higher mortality compared to SRH presenting time at >12 h of age (odds ratio 25.0, 95% CI 2.514–248.575, p = 0.001).
Conclusion: Our literature review revealed that the mortality rate of neonatal SRH was 18% and that the mortality risk was higher in neonates presenting with SRH symptoms and signs at ≤12 h of age.
Introduction
Intra-abdominal hemorrhage, especially the splenic hemorrhage, is a rare event in neonates (1). The incidence of splenic rupture or hemorrhage is unknown, reflecting its rarity (2). The initial symptoms of neonatal splenic rupture/hemorrhage (SRH) are non-specific which may lead to the delayed diagnosis in some cases. Despite the potential fatality, SRH can spontaneously resolve without surgical treatment. Appropriate treatment strategies for neonatal SRH remain controversial. Herein, we report the cases of two neonates with SRH and review the other cases of neonatal SRH in the English-language literature, with the aim to describe the clinical features of neonatal SRH, to summarize therapies and outcomes, and to elucidate risk factors for mortality in neonates presenting with this rare condition.
Patients and Methods
Case Reports
Case 1
A baby girl was delivered at term to a gravida 2, para 1 mother through cesarean section due to fetal distress and placental abruption. Her birth weight (BW) was 2,460 g, and the 1 and 5 min Apgar scores were 6 and 7, respectively. After birth, the patient was flaccid and cyanotic. She was intubated and immediately resuscitated and with transfer to our hospital due to perinatal asphyxia.
At arrival to our hospital, the patient was pale and lethargic. Her vital signs were as follows: rectal temperature 36°C, pulse rate, 100/min; respiration rate 50/min, and blood pressure, 30/10 mmHg. She was ventilated with high frequency oscillation ventilation. Inotropic agents, blood transfusion and fluid resuscitation were administered. Laboratory data indicated metabolic acidosis. Additional laboratory parameters as follows: hemoglobin (Hb), 8.8 g/dL; the white blood cell count (WBCs), 13.9 × 103/uL, and platelet counts 190 × 103/uL. The prothrombin time (PT) and activated partial thromboplastin times were prolonged. The fibrinogen and D-dimer were <50 mg/dl and >10,000 FEU ng/mL. The Coombs test was negative. Cranial ultrasonography did not reveal intracranial or intraventricular hemorrhage. Perinatal asphyxia associated with maternal placental abruption and stage II hypoxic ischemic encephalopathy (HIE) were suspected. Therapeutic hypothermia was commenced at 5 h of age and erythropoietin was used as an adjuvant therapy. Abdominal ultrasound to investigate the cause of neonatal anemia revealed bloody ascites and splenic rupture with hemorrhage, and abdominal distension was noted during the evaluation. Emergent exploratory laparotomy and splenectomy were performed on the 1 day-old patient. During the laparostomy, massive hemoperitoneum, and splenic laceration with active bleeding were noted. Despite treatment, severe acute kidney injury, pulmonary hypertension and severe intraventricular hemorrhage occurred and was administered palliative treatment because of the expected poor outcome and high mortality.
Case 2
This 2 day-old female infant was delivered at gestational age of 39 weeks to a gravida 1 para 1 mother through vaginal delivery with a BW of 3,340 gm at an outside hospital. Apgar scores were 8 and 9 at 1 and 5 min, respectively. The antenatal examination was unremarkable. However, she developed pallor at 2 days of age; tachycardia and decreased activity were observed as well. Laboratory examination revealed severe anemia.
Physical examination on arrival at our hospital revealed pale appearance. Her vital signs were as follows: rectal temperature of 36.3°C; pulse rate, 143/min; respiration rate 26/min and blood pressure, 76/54 mmHg. Laboratory examination revealed the following: Hb 5.4 g/dL; WBCs, 17.92 × 103/uL, and platelet count 207 × 103/uL. Abdominal ultrasonography revealed an enlarged spleen and a heterogenous mass (4.0 × 3.7 × 3.8 cm) in left upper abdomen; thus, splenic laceration with hematoma and bleeding was suspected. Abdominal computed tomography (CT) scan showed peri-splenic hematoma, ~3.5 × 3 cm in size, and hemoperitoneum indicating splenic laceration. After blood transfusion and fluid replace therapy, the patient stabilized and her follow-up hemoglobin level was 17.4 g/dL. She was discharged without any complications.
Patient Population
We used the keywords “neonatal splenic rupture,” “neonatal splenic laceration,” “neonatal splenic hemorrhage,” and “neonatal splenic hematoma,” to search articles in the PUBMED databases and reviewed those published articles from their inception between January 1968 and December 2019. In addition to the two cases presented herein, we identified 37 cases of neonatal SRH in the English-language literature.
Data Collection and Statistical Analysis
This study was approved by the ethics committee of Chang Gung Medical Hospital which waived the requirement for informed consent to collect anonymized data. Demographic data, precipitating factors, clinical characteristics including presenting symptoms and signs, time of onset, imaging findings, treatments, and outcomes were collected and analyzed. Preterm birth was defined as birth before 37 weeks of gestation. Low birth weight was defined as BW < 2,500 g. Age of SRH presentation was defined as the time of the emergence of first symptoms or signs after birth. Categorical variables were reported as absolute numbers and percentages and analyzed using chi-square or Fisher' s exact test. Continuous variables were analyzed using parametric or non-parametric tests as appropriate. Continuous variables were reported as means with standard deviation for parametric data and as medians with interquartile range for non-parametric data. Risk factors for mortality were analyzed by univariate logistic regression and presented as odds ratios (OR) with 95% confidence intervals (CI). A p < 0.05 was considered to indicate statistical significance. The IBM SPSS statistics package, version 21 (IBM Corp., Armonk, NY, USA) was used for all statistical analyses.
Results
There were 39 neonates with the diagnosis of SRH during the study period. The demographic data and detailed information on these 39 cases are presented in Table 1. The rates of full-term and preterm neonates were 72% (28/39) and 18% (11/39), respectively. The median BW was 3,200 (2,470–3,620) g, and four neonates were large for gestational age (LGA, BW > 4,000 g). Additionally, 74% (29/39) of the patients were delivered through vaginal delivery whereas the remaining patients 26% (10/39) were delivered through cesarean section. The time of SRH presentation ranged between 3 h and 5 days of age. The precipitating factors included prolonged labor (n = 3), birth trauma (n = 2), breech (n = 1), wandering spleen (n = 1), assaulted before delivery (n = 1), post resuscitation (n = 5), congenital deficiency in coagulation factor VII deficiency (n = 1), erythroblastosis fetalis (n = 4), hemophilia A (n = 3), family history of hemophilia A (n = 1), and preterm neonate (n = 11). Therefore, the rate of congenital coagulation disorders (congenital coagulation factor VII and hemophilia A) was 13% in the current cohort.
Table 1. Clinical characteristics of neonates with splenic rupture.
The review of all reported reports revealed that the initial presenting symptoms and signs included pallor or anemia (n = 23), abdominal discoloration/distension (n = 23), tachycardia/shock (n = 10), scrotal hematoma or swollen (n = 7), lethargy (n = 5), vomiting (n = 4), poor feeding (n = 3), and death (n = 1). Abdominal ultrasonography was performed in 24 neonates; eight of these neonates were also evaluated by abdominal CT as an adjuvant diagnostic tool. Four neonates underwent abdominal CT as the initial diagnostic tool. Twenty-seven neonates (69%) received surgical treatment; 16 neonates received splenectomy; 6 neonates received repair of the spleen rupture with tissue-glue or surgery; 1 neonate received the peritoneal flap; 1 neonate was managed with splenic auto-transplantation; 3 neonates underwent exploratory laparotomy only. There were seven death in this study cohort; therefore the mortality rate was 18% (7/39). Case 13 was found dead at 7 h of age by the nurse; case 32 died at 72 h of age due to severe hyperkalemia with a heart rhythm disorder; case 34 died at 55 h of age; case 35 died at 103 h of age due to massive pulmonary hemorrhage with refractory hypoxemia; case 36 died at 60 h of age, and case 38 died at 1 month of age after withdrawal of life support. None of the remaining 32 survivors (82%) exhibited neurologic sequelae, developmental delays or growth retardation.
Table 2 shows the clinical features associated with mortality. The mortality group had statistically significant higher rates of vaginal delivery (p = 0.041, odds ratio = 0.144, 95% CI 0.024–0.853). The age of presentation with neonatal SRH was associated with poor outcome. The odds ratio for mortality was 25.0 (95% CI 2.514–248.575, p = 0.001) in neonates presenting with SRH at ≤12 h of age compared to those presenting with SRH >12 h of age. The mortality group had lower age of presentation with neonatal SRH that the median age was 3 h (IQR 1–7). Preterm birth, low BW, prolong labor, birth trauma, resuscitation, 1 min of Apgar score, 5 min of Apgar score, congenital coagulation disorders, hemoglobin level, or splenectomy were not statistically associated with mortality.
Table 2. Risk factors associated with mortality in neonates with splenic rupture/hemorrhage.
Discussion
We herein presented an uncommon presentation of SRH (case 1) in the cooling era for perinatal HIE. Based on our experience in two cases and the analysis of available literature, presentation at ≤12 h of age was a risk factor for mortality in neonates with SRH. As a rare cause of hemoperitoneum in neonates, splenic injury is less frequently than injury to the liver or adrenal glands due to its well-protected position in the left upper abdominal quadrant (20). The triad of anemia, abdominal distension and shock has been described as typical clinical presentation of intra-abdominal hemorrhage in neonates (1). Clinicians should suspect abdominal hemorrhage if patients had unexplained anemia. Hepatic lesions (65%) account for the most frequent causes of intra-abdominal hemorrhage, followed by adrenal lesions (15%) and splenic lesion (10%) (30). Hepatic laceration should be considered if the patient underwent umbilical venous catheter insertion (32). Patients had history of hypoxia before or during delivery may lead to adrenal gland hemorrhage because the increased pressure with congestion and the damaged endothelial cells (33, 34).
Case 1 neonate presented herein was born to a mother with placental abruption and was diagnosed as perinatal asphyxia with stage II HIE. Therapeutic hypothermia was performed as recommended (35). Abdominal ultrasonography performed based on the observed anemia and progressive abdominal distension revealed splenic rupture with hemorrhage. Case 1 neonate, who was at high mortality risk according to our review and analysis, nonetheless highlights that SRH can be a cause or a comorbid condition in neonates with perinatal HIE undergoing therapeutic hypothermia.
On our review, vaginal delivery was significantly associated with mortality which is thought increased intrathoracic pressure during vaginal delivery pushing the spleen into the abdominal cavity, and exposing it to direct splenic trauma through the birth canal during labor (29). Gruenwald et al. indicated that the intrathoracic pressure that forces the liver or spleen out of the diaphragm hallow can cause severe tension in their supported ligaments (36). Splenic rupture and splenic hemorrhage occur in two stages. The first stage is subcapsular hematoma formation, which is often asymptomatic, whereas the second stage is capsular rupture which leads to the development of acute symptoms of decompensation and the rapid onset of hypovolemic shock (30). The present study revealed that early presentation at ≤12 h of age was associated with poor prognosis. Splenic rupture/hemorrhage in neonates can present either within the first few hours of life or as late as the second week of life, following the rupture of the splenic capsule. In addition, splenic injury can range from the superficial lacerations to the parenchymal hemorrhage. Altogether, early presentation after birth might imply severe and extensive splenic injury, leading to earlier emergence of symptoms present earlier and difficult to recovery.
We also found that the most common presenting symptoms and signs of SRH were pallor or anemia, followed by abdominal discoloration/distension. In the present study, we also noted that 18% (7/39) of all reported cases of neonatal SRH presented with scrotal hematoma or swelling. Most of the affected neonates (74%) were born through vaginal delivery, and four out of them (14%) were LGA neonates. Higher birth weight is not a precipitating factor leading to SRH. Regarding precipitating and risk factors, most cases of neonatal SRH were idiopathic. However, previous studies reported that splenic rupture occurs in those with an abnormal spleen such as those with erythroblastosis (6, 7, 37). Congenital coagulation disorders accounted for 13% (5/39) of SRH of all neonatal SRH cases in the present study cohort. Therefore, investigation for congenital coagulation disorders is recommended in neonates with SRH.
Based on our literature review, the prognosis was comparable between patients who received non-surgical treatment and those who underwent splenectomy. The first case of neonatal SRH who recovered after surgical treatment was reported by Rogers in 1934 (38). Splenectomy has been considered as the first line of treatment for neonatal SRH in the past decade (36), and the preservation of the spleen is desirable (39). Recent studies recommend non-surgical management as the first-line of therapy for SRH due to the risk of overwhelming post splenectomy sepsis (14, 17, 40). Studies also indicated that children are at higher risk of post-splenectomy sepsis compared with adults (40, 41). In addition, advances in ultrasound technology allow the definitive diagnosis of causes underlying intra-abdominal hemorrhage such as renal and splenic hemorrhage (42, 43). Computed tomography to evaluate the severity of splenic trauma may also provide safe non-surgical management in these patients (44). With recent improvement in diagnostic imaging and alternative approaches, splenectomy is no longer a priority. Our literature review reveals that long-term outcome is favorable in neonates who survive SRH.
The present study has several limitations. First, the small sample size of the study might have affected the statistical analysis. However, neonatal SRH is extremely rare and the current study included the largest cohort in statistical analyses. Additionally, the retrospective study designs might have introduced bias.
Conclusion
The mortality of neonatal splenic rupture/hemorrhage was 18% in this study. Vaginal delivery and the presentation at ≤12 h of age were risk factors for mortality. Investigation for congenital coagulation disorders is recommended in neonate with SRH.
Data Availability Statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Ethics Statement
The studies involving human participants were reviewed and approved by the ethics committee of Chang Gung Medical Hospital. Written informed consent for participation was not provided by the participants' legal guardians/next of kin because: this retrospective study was approved by the ethics committee of Chang Gung Medical Hospital and waived the requirement to obtain informed consent of collecting anonymized data.
Author Contributions
H-PC conceived the study, collected information from the literature, and drafted the manuscript. R-HF and J-JL provided professional guidance and manuscript modification. M-CC conceived the study, provided professional guidance, and manuscript modification. All authors contributed to the article and approved the submitted version.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Keywords: neonates, spleen, splenic hematoma, splenic hemorrhage, splenic laceration, splenic rupture
Citation: Chang H-P, Fu R-H, Lin J-J and Chiang M-C (2021) Prognostic Factors and Clinical Features of Neonatal Splenic Rupture/Hemorrhage: Two Cases Reports and Literature Review. Front. Pediatr. 9:616247. doi: 10.3389/fped.2021.616247
Received: 11 October 2020; Accepted: 04 January 2021;
Published: 25 January 2021.
Edited by:
Karel Allegaert, University Hospitals Leuven, BelgiumReviewed by:
Bruno Martinez-Leo, Universidad Nacional Autónoma de México, MexicoTuuli Metsvaht, University of Tartu, Estonia
Copyright © 2021 Chang, Fu, Lin and Chiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ming-Chou Chiang, newborntw@gmail.com