AUTHOR=Fraser Douglas D. , Patterson Eric K. , Daley Mark , Cepinskas Gediminas 

TITLE=Case Report: Inflammation and Endothelial Injury Profiling of COVID-19 Pediatric Multisystem Inflammatory Syndrome (MIS-C)

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.597926

DOI=10.3389/fped.2021.597926

ISSN=2296-2360

ABSTRACT=<p><bold>Introduction:</bold> COVID-19 is associated with a novel multi-system inflammatory syndrome that shares some characteristics with Kawasaki's Disease. The syndrome manifestation is delayed relative to COVID-19 onset, with a spectrum of clinical severity. Clinical signs may include persistent fever, gastrointestinal symptoms, cardiac inflammation and/or shock.</p><p><bold>Case Presentation:</bold> We measured 59 inflammatory and endothelial injury plasma analytes in an adolescent girl that presented with malaise, fever, cough, strawberry tongue and jaundice. Her COVID-19 status was positive with detection of 2 SARS-CoV-2 viral genes using polymerase chain reaction. She was treated with intravenous immunoglobulin prior to blood draw, but our plasma measurements suggested a unique analyte expression pattern associated with inflammation, endothelial injury and microvascular glycocalyx degradation.</p><p><bold>Conclusions:</bold> COVID-19 is associated with a multi-system inflammatory syndrome and a unique inflammatory and endothelial injury signature.</p><p><bold>Summary:</bold> Analyte markers of inflammation and endothelial cell injury might serve as putative biomarkers and/or be investigated further as potential therapeutic targets.</p>