AUTHOR=Zhang Qingyou , Sun Yan , Zhang Chunyu , Qi Jianguang , Du Junbao 

TITLE=Vitamin D Deficiency and Vasovagal Syncope in Children and Adolescents

JOURNAL=Frontiers in Pediatrics

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.575923

DOI=10.3389/fped.2021.575923

ISSN=2296-2360

ABSTRACT=<p><bold>Aims:</bold> To investigate the association of vitamin D deficiency with cardiovascular autonomic nervous system function in children and adolescents with vasovagal syncope (VVS).</p><p><bold>Methods:</bold> This study recruited 76 pediatric patients with VVS and 15 healthy children. The 25-hydroxyvitamin D levels in serum among the participants were evaluated. Heart rate variability analysis including SDNN, rMSSD, and SDANN was tested in patients with VVS. The correlation between indices of time-domain analysis and serum vitamin D status of the children with VVS was investigated.</p><p><bold>Results:</bold> In this work, 25-hydroxyvitamin D levels in serum among VVS cases remarkably decreased compared with those among healthy controls (48.76 ± 19.25 vs. 67.62 ± 15.46 nmol/L, <italic>p</italic> &lt; 0.01). The vitamin D deficient patients with VVS exhibited a lower rMSDD value compared to the non-deficient group with VVS (45.56 ± 16.87 vs. 61.90 ± 20.38 ms, <italic>p</italic> &lt; 0.001, respectively). Pearson correlation analysis indicated that serum 25-hydroxyvitamin D levels had positive correlation with rMSDD values (<italic>r</italic> = 0.466, <italic>p</italic> &lt; 0.001).</p><p><bold>Conclusions:</bold> As suggested by our data, VVS children and adolescents with vitamin D deficiency may have cardiac autonomic dysfunction and cardiac vagal tone decreases with the reduction in vitamin D level.</p>