AUTHOR=Dolejs Josef , Homolková Helena 

TITLE=Why Does Child Mortality Decrease With Age? Modeling the Age-Associated Decrease in Mortality Rate Using WHO Metadata From 14 European Countries

JOURNAL=Frontiers in Pediatrics

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2020.527811

DOI=10.3389/fped.2020.527811

ISSN=2296-2360

ABSTRACT=<p><bold>Background:</bold> Mortality rate rapidly decreases with age after birth, and, simultaneously, the spectrum of death causes show remarkable changes with age. This study analyzed age-associated decreases in mortality rate from diseases of all main chapters of the 10th revision of the International Classification of Diseases.</p><p><bold>Methods:</bold> The number of deaths was extracted from the mortality database of the World Health Organization. As zero cases could be ascertained for a specific age category, the Halley method was used to calculate the mortality rates in all possible calendar years and in all countries combined.</p><p><bold>Results:</bold> All causes mortality from the 1st day of life to the age of 10 years can be represented by an inverse proportion model with a single parameter. High coefficients of determination were observed for total mortality in all populations (arithmetic mean = 0.9942 and standard deviation = 0.0039).</p><p>Slower or no mortality decrease with age was detected in the 1st year of life, while the inverse proportion method was valid for the age range [1, 10) years in most of all main chapters with three exceptions.
<list list-type="alpha-lower"><list-item><p>The decrease was faster for the chapter “Certain conditions originating in the perinatal period” (XVI).</p></list-item><list-item><p>The inverse proportion was valid already from the 1st day for the chapter “Congenital malformations, deformations and chromosomal abnormalities” (XVII).</p></list-item><list-item><p>The shape of the mortality decrease was very different for the chapter “Neoplasms” (II) and the rates of mortality from neoplasms were age-independent in the age range [1, 10) years in all populations.</p></list-item></list></p><p><bold>Conclusion:</bold> The theory of congenital individual risks of death is presented and can explain the results. If it is valid, latent congenital impairments may be present among all cases of death that are not related to congenital impairments. All results are based on published data, and the data are presented as a supplement.</p>