AUTHOR=Ma Xueling , Wu Xiushuang , Shi Yuan 

TITLE=Changes of Dynamic Functional Connectivity Associated With Maturity in Late Preterm Infants

JOURNAL=Frontiers in Pediatrics

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2020.00412

DOI=10.3389/fped.2020.00412

ISSN=2296-2360

ABSTRACT=<p><bold>Objective:</bold> To investigate the changes of dynamic functional connectivity (DFC) in late preterm infants, and assess whether these changes are associated with the indicators measuring the maturity of neonates.</p><p><bold>Methods:</bold> Resting-state fMRI (rs-fMRI) data of eligible neonates was acquired with a 3.0-T MRI scanner in the Department of Radiology, Daping Hospital, Army Medical University (Chongqing, China). After the selection of functional connectivity networks obtained by independent component analysis (ICA), a sliding-window approach was used to cluster all the windows into different states. Then the differences of temporal properties of DFC between groups were compared, and the association between these temporal properties and the degree of maturity was also explored in each state.</p><p><bold>Results:</bold> Eventually, 34 late preterm and 37 term neonates were included in the final analysis. Based on their data, 5 components were located in 5 networks: default-mode (DMN), dorsal attention (DAN), auditory (AUD), sensorimotor (SMN), and visual (VN). Then four reoccurring state patterns of functional connectivity were identified with the k-means clustering method. The late preterm group dwelled significantly longer in State III (late preterm: 33.57 ± 37.64 s, term: 18.50 ± 11.71 s; <italic>P</italic> = 0.03), which was characterized by general weaker connectivity between networks. Also, the correlation analysis shows the degree of maturity is negatively correlated to the dwell time and fractional windows in State III.</p><p><bold>Conclusion:</bold> Our findings suggested that compared with term infants, late preterm infants preferred to stay in a state with general weak connectivity between networks, but this preference declined as maturity increased.</p>