AUTHOR=Ksiazek Teofila , Czogala Malgorzata , Kaczowka Przemyslaw , Sadowska Beata , Pawinska-Wasikowska Katarzyna , Bik-Multanowski Mirosław , Sikorska-Fic Barbara , Matysiak Michał , Skalska-Sadowska Jolanta , Wachowiak Jacek , Rodziewicz-Konarska Anna , Chybicka Alicja , Muszynska-Rosłan Katarzyna , Krawczuk-Rybak Maryna , Grabowski Dominik , Kowalczyk Jerzy , Maciejka-Kemblowska Lucyna , Adamkiewicz-Drozynska Elzbieta , Mlynarski Wojciech , Tomaszewska Renata , Szczepanski Tomasz , Pohorecka Joanna , Karolczyk Grazyna , Mizia-Malarz Agnieszka , Mycko Katarzyna , Badowska Wanda , Zielezinska Karolina , Urasinski Tomasz , Karpinska-Derda Irena , Woszczyk Mariola , Ciebiera Małgorzata , Lejman Monika , Skoczen Szymon , Balwierz Walentyna 

TITLE=High Frequency of Fusion Gene Transcript Resulting From t(10;11)(p12;q23) Translocation in Pediatric Acute Myeloid Leukemia in Poland

JOURNAL=Frontiers in Pediatrics

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2020.00278

DOI=10.3389/fped.2020.00278

ISSN=2296-2360

ABSTRACT=<p>11q23/<italic>MLL</italic> rearrangements are frequently detected in pediatric acute myeloid leukemia. The analysis of their clinical significance is difficult because of the multitude of translocation fusion partners and their low frequency. The presence of t(10;11)(p12;q23) translocation was previously identified in pediatric acute myelogenous leukemia (AML). It is considered as the second most common translocation detected in pediatric 11q23/<italic>MLL</italic>-rearranged (present <italic>KMT2A</italic>) AML, after t(9;11)(p22;q23). The presence of the above translocation was previously identified as an unfavorable prognostic factor. Since June 2015, the Polish Pediatric Leukemia/Lymphoma Study Group has applied the therapeutic protocol requiring extensive diagnostics of genetic changes in pediatric AML. Until November 2019, molecular genetic studies were performed in 195 children with diagnosed AML to identify carriers of fusion gene transcripts for 28 most common chromosomal translocations in acute leukemia. The fusion gene transcript for translocation t(10;11)(p12;q23) involving <italic>MLL</italic> gene was detected with unexpectedly high frequency (8.9%) in our research. It was the highest frequency of all detected <italic>MLL</italic> rearrangements, as well as other detected fusion gene transcripts from chromosomal aberrations characteristic for AML. It seems that chromosomal aberration between chromosomes 10 and 11 can be relatively frequent in some populations. Paying attention to this fact and ensuring proper genetic diagnosis seem to be important for appropriate allocation of patients to risk groups of pediatric AML treatment protocols.</p>