AUTHOR=Kentsis Alex , Frank Steven A. TITLE=Developmental Mutators and Early Onset Cancer JOURNAL=Frontiers in Pediatrics VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2020.00189 DOI=10.3389/fped.2020.00189 ISSN=2296-2360 ABSTRACT=

A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.