AUTHOR=Garazzino Silvia , Altieri Elena , Silvestro Erika , Pruccoli Giulia , Scolfaro Carlo , Bignamini Elisabetta 

TITLE=Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data

JOURNAL=Frontiers in Pediatrics

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2020.00173

DOI=10.3389/fped.2020.00173

ISSN=2296-2360

ABSTRACT=<p>Ceftolozane-tazobactam is a novel fifth-generation cephalosporin/β-lactamase inhibitor combination recently approved for treatment of both complicated intra-abdominal and urinary tract infections in adults. Considering its potent bactericidal activity against <italic>Pseudomonas aeruginosa</italic>, it might represent an important option also for treating children with exacerbations of cystic fibrosis due to <italic>Pseudomonas aeruginosa</italic> when other alternative treatments have been exhausted. We hereby review available data on the use of ceftolozane-tazobactam in children, focusing on cystic fibrosis.</p>