AUTHOR=Kurteva Elena , Bamford Alasdair , Cross Kate , Watson Tom , Owens Catherine , Cheng Fanlek , Hartley John , Harris Kathryn , Johnson Elizabeth M. , Lindley Keith , Levine Samantha , Köglmeier Jutta 

TITLE=Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation

JOURNAL=Frontiers in Pediatrics

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2020.00142

DOI=10.3389/fped.2020.00142

ISSN=2296-2360

ABSTRACT=<p>Basidiobolomycosis is a rare fungal disease caused by <italic>Basidiobolus ranarum</italic>. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of <italic>Basidiobolus</italic>. He made a full recovery with a combination of surgery and prolonged targeted antifungal medication.</p>