AUTHOR=Bannier Michiel A. G. E. , Rosias Philippe P. R. , Jöbsis Quirijn , Dompeling Edward 

TITLE=Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

JOURNAL=Frontiers in Pediatrics

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2019.00150

DOI=10.3389/fped.2019.00150

ISSN=2296-2360

ABSTRACT=<p>Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.</p>