AUTHOR=Vaterodt Laura , Holle Johannes , Hüseman Dieter , Müller Dominik , Thumfart Julia 

TITLE=Short- and Long-Term Renal Outcome of Hemolytic-Uremic Syndrome in Childhood

JOURNAL=Frontiers in Pediatrics

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2018.00220

DOI=10.3389/fped.2018.00220

ISSN=2296-2360

ABSTRACT=<p><bold>Introduction:</bold> Hemolytic-uremic syndrome (HUS) is a common cause for intrarenal acute kidney injury in childhood. More than 90% of HUS cases are associated with an infection by Shigatoxin-producing <italic>Escherichia coli</italic> (STEC) whereas the reminder comprises a heterogeneous group (here classified as Non-STEC-HUS). Renal impairment can persist in patients with HUS. This study presents data from four decades investigating the short- and long-term outcome of HUS in childhood.</p><p><bold>Materials and Methods:</bold> In a retrospective single-center-study clinical and laboratory data of the acute phase and of 1- to 10-year follow-up visits of children with HUS were analyzed.</p><p><bold>Results:</bold> 92 HUS-patients were identified from 1996 to 2014 (STEC-HUS-group: <italic>n</italic> = 76; Non-STEC-HUS-group: <italic>n</italic> = 16) and 220 HUS-patients between 1976 and 1995. STEC-HUS was increasingly caused by Non-O157 strains and mortality rate declined over the past decades (1.3 vs. 9.5%). Renal sequelae persisted more often in the group 1976–1995 (39.3%) than in the group 1996–2014 (28.3%), but more than 50% of all patients were lost to follow-up.</p><p><bold>Conclusion:</bold> Although renal outcome has improved over the investigated last decades, patients with HUS still face a high risk of permanent renal damage. These findings underline the importance of a consequent long-term follow-up in HUS-patients.</p>