AUTHOR=Canetta Pietro A. A. , Radhakrishnan Jai 

TITLE=The Evidence-Based Approach to Adult-Onset Idiopathic Nephrotic Syndrome

JOURNAL=Frontiers in Pediatrics

VOLUME=3

YEAR=2015

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2015.00078

DOI=10.3389/fped.2015.00078

ISSN=2296-2360

ABSTRACT=<p>Adult-onset nephrotic syndrome (NS) differs from its pediatric counterpart in several important ways. Most importantly, NS in adults is more etiologically heterogeneous compared to children, and thus treatment approaches rely heavily on the histological diagnosis provided by renal biopsy. The evidence-based approach to treatment of adult NS has been critically examined by the Kidney Disease Improving Global Outcomes (KDIGO) guidelines in glomerulonephritis, published in 2012. Here, we examine the strengths and limits of those guidelines and review recent work that expands the evidence-based approach.</p>