AUTHOR=Bhuiyan M. Z. A. , Al-Shahrani Safar , Al-Aama Jumana , Wilde Arthur , Momenah Tarek S. TITLE=Congenital Long QT Syndrome: An Update and Present Perspective in Saudi Arabia JOURNAL=Frontiers in Pediatrics VOLUME=1 YEAR=2013 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2013.00039 DOI=10.3389/fped.2013.00039 ISSN=2296-2360 ABSTRACT=
Primary cardiac arrhythmias are often caused by defects, predominantly in the genes responsible for generation of cardiac electrical potential, i.e., cardiac rhythm generation. Due to the variability in underlying genetic defects, type, and location of the mutations and putative modifiers, clinical phenotypes could be moderate to severe, even absent in many individuals. Clinical presentation and severity could be quite variable, syncope, or sudden cardiac death could also be the first and the only manifestation in a patient who had previously no symptoms at all. Despite usual familial occurrence of such cardiac arrhythmias, disease causal genetic defects could also be