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ORIGINAL RESEARCH article

Front. Pain Res.
Sec. Pharmacological Treatment of Pain
Volume 5 - 2024 | doi: 10.3389/fpain.2024.1500789

Systemic Antihyperalgesic Effect of a Novel Conotoxin from Californiconus californicus in an Inflammatory Pain Model

Provisionally accepted
Joaquín López-Carrillo Joaquín López-Carrillo 1Johanna Bernáldez-Sarabia Johanna Bernáldez-Sarabia 1Tushar J Pawar Tushar J Pawar 2Samanta Jiménez Samanta Jiménez 1Salvador Dueñas Salvador Dueñas 1Vinicio Granados-Soto Vinicio Granados-Soto 3Andrea Figueroa-Montiel Andrea Figueroa-Montiel 1José L Olivares-Romero José L Olivares-Romero 2Alexei Fedorovish Licea Navarro Alexei Fedorovish Licea Navarro 1*Nadia L Caram-Salas Nadia L Caram-Salas 1,4*
  • 1 Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Baja California, Mexico
  • 2 Instituto de Ecología (INECOL), Xalapa, Veracruz, Mexico
  • 3 Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados, Instituto Politécnico Nacional de México (CINVESTAV), Mexico City, México, Mexico
  • 4 National Council of Science and Technology (CONACYT), Benito Juárez, Mexico

The final, formatted version of the article will be published soon.

    This work studied the analgesic potential of the novel conotoxin O1_cal6.4b, derived from Californiconus californicus, in a model of inflammatory pain. Systemic administration of the conotoxin to Wistar rats diminished in a dose-dependent manner thermal hyperalgesia without alteration of motor coordination. O1_cal6.4b induced a superior effect compared with O1_cal6.4d and ω-MVIIA. In addition, the effect of this drug was greater than those induced by morphine, dexamethasone, and diclofenac. Structural differences between O1_cal6.4d and O1_cal6.4d, as revealed through in silico modeling and molecular dynamics, highlight the need for further investigation of its action mechanism. This novel conotoxin grants promise in pain management, suggesting potential advantages over traditional opioid-based therapies. The study provides insights into the molecular diversity of conotoxins and paves the way for innovative analgesic treatments.

    Keywords: Conotoxin systemic administration, Californiconus californicus, Chronic pain treatments, Analgesia, Inflammatory pain

    Received: 23 Sep 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 López-Carrillo, Bernáldez-Sarabia, Pawar, Jiménez, Dueñas, Granados-Soto, Figueroa-Montiel, Olivares-Romero, Licea Navarro and Caram-Salas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Alexei Fedorovish Licea Navarro, Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Baja California, 22860, Mexico
    Nadia L Caram-Salas, National Council of Science and Technology (CONACYT), Benito Juárez, Mexico

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