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REVIEW article

Front. Pain Res.
Sec. Pharmacological Treatment of Pain
Volume 5 - 2024 | doi: 10.3389/fpain.2024.1452389

The mechanism and potential therapeutic target of Piezo Channels in pain

Provisionally accepted
Yi Xu Yi Xu 1Yuheng Wang Yuheng Wang 1Shuchong Mei Shuchong Mei 2Lidong Wu Lidong Wu 2Luyang Xu Luyang Xu 2Jialing Hu Jialing Hu 2*Bao Lijie Bao Lijie 2Xiaowei Fang Xiaowei Fang 2
  • 1 Nanchang University, Nanchang, Jiangxi Province, China
  • 2 Department of Emergency Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China

The final, formatted version of the article will be published soon.

    Pain is a common symptom of many clinical diseases; it adversely affects patients' physical and mental health, reduces their quality of life, and heavily burdens patients and society. Pain treatment is one of the most difficult problems today. There is an urgent need to explore the potential factors involved in the pathogenesis of pain to improve its diagnosis and treatment rate. Piezo1/2, a newly identified mechanosensitive ion channel opens in response to mechanical stimuli and plays a critical role in regulating pain-related diseases. Inhibition or downregulation of Piezo1/2 alleviates disease-induced pain. Therefore, in this study,we comprehensively discussed the biology of this gene, focusing on its potential relevance in pain-related diseases, and explored the pharmacological effects of drugs using this gene for the treatment of pain.

    Keywords: ：Piezo1, Piezo2, Therapeutic target, Pain, Ca2+

    Received: 20 Jun 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Xu, Wang, Mei, Wu, Xu, Hu, Lijie and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jialing Hu, Department of Emergency Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.