AUTHOR=Aviram Joshua , Lewitus Gil M. , Vysotski Yelena , Amna Mahmoud Abu , Ouryvaev Anton , Procaccia Shiri , Cohen Idan , Leibovici Anca , Akria Luiza , Goncharov Dimitry , Mativ Neomi , Kauffman Avia , Shai Ayelet , Bar-Sela Gil , Meiri David TITLE=The Effectiveness and Safety of Medical Cannabis for Treating Cancer Related Symptoms in Oncology Patients JOURNAL=Frontiers in Pain Research VOLUME=3 YEAR=2022 URL=https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2022.861037 DOI=10.3389/fpain.2022.861037 ISSN=2673-561X ABSTRACT=

The use of medical cannabis (MC) to treat cancer-related symptoms is rising. However, there is a lack of long-term trials to assess the benefits and safety of MC treatment in this population. In this work, we followed up prospectively and longitudinally on the effectiveness and safety of MC treatment. Oncology patients reported on multiple symptoms before and after MC treatment initiation at one-, three-, and 6-month follow-ups. Oncologists reported on the patients' disease characteristics. Intention-to-treat models were used to assess changes in outcomes from baseline. MC treatment was initiated by 324 patients and 212, 158 and 126 reported at follow-ups. Most outcome measures improved significantly during MC treatment for most patients (p < 0.005). Specifically, at 6 months, total cancer symptoms burden declined from baseline by a median of 18%, from 122 (82–157) at baseline to 89 (45–138) at endpoint (−18.98; 95%CI= −26.95 to −11.00; p < 0.001). Reported adverse effects were common but mostly non-serious and remained stable during MC treatment. The results of this study suggest that MC treatment is generally safe for oncology patients and can potentially reduce the burden of associated symptoms with no serious MC-related adverse effects.