AUTHOR=Bella Ariadni , Diego Alba M. , Finn David P. , Roche Michelle 

TITLE=Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models

JOURNAL=Frontiers in Pain Research

VOLUME=3

YEAR=2023

URL=https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2022.1106143

DOI=10.3389/fpain.2022.1106143

ISSN=2673-561X

ABSTRACT=<p>Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the main risk factors for the development of chronic post-surgical pain. Clinically valid animal models provide an important means of examining the mechanisms underlying the effects of stress on post-surgical pain and identifying potential novel therapeutic targets. This review discusses the current data from preclinical animal studies examining the effect of stress on post-surgical pain, the potential underlying mechanisms and gaps in the knowledge that require further investigation.</p>