AUTHOR=Redwood Emily , Lam Virginie , Takechi Ryusuke , Kerr Deborah Anne , Jackaman Connie , Sharif Arazu , Mamo John Charles Louis 

TITLE=Aged garlic extract as a potential prophylactic to reduce the progression of endometriosis and associated pain burden

JOURNAL=Frontiers in Pain Research

VOLUME=3

YEAR=2022

URL=https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2022.1057830

DOI=10.3389/fpain.2022.1057830

ISSN=2673-561X

ABSTRACT=<p>Endometriosis is a complex and potentially debilitating condition that has major impact on quality of life. There is emerging evidence that biological compounds found in garlic (<italic>Allium sativum</italic>) may be effective for attenuating endometrial pain. Suggested mechanisms for efficacy include modulation of inflammation and potent antioxidant effects. Aged-garlic-extract (AGE) is a centuries old process describing ethanolic extracts of garlic bulbs for 12–20 months. The AGE formulation realised contains a complex array of stabilised biologics with significant immunomodulatory effects relevant to inflammatory conditions. This perspective article puts forward a hypothesis that AGE should be considered as a prophylactic to manage endometrial pain.</p>