AUTHOR=Liu Yaling , Xu Helen , Sun Guanghao , Vemulapalli Bharat , Jee Hyun Jung , Zhang Qiaosheng , Wang Jing TITLE=Frequency Dependent Electrical Stimulation of PFC and ACC for Acute Pain Treatment in Rats JOURNAL=Frontiers in Pain Research VOLUME=2 YEAR=2021 URL=https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2021.728045 DOI=10.3389/fpain.2021.728045 ISSN=2673-561X ABSTRACT=

As pain consists of both sensory and affective components, its management by pharmaceutical agents remains difficult. Alternative forms of neuromodulation, such as electrical stimulation, have been studied in recent years as potential pain treatment options. Although electrical stimulation of the brain has shown promise, more research into stimulation frequency and targets is required to support its clinical applications. Here, we studied the effect that stimulation frequency has on pain modulation in the prefrontal cortex (PFC) and the anterior cingulate cortex (ACC) in acute pain models in rats. We found that low-frequency stimulation in the prelimbic region of the PFC (PL-PFC) provides reduction of sensory and affective pain components. Meanwhile, high-frequency stimulation of the ACC, a region involved in processing pain affect, reduces pain aversive behaviors. Our results demonstrate that frequency-dependent neuromodulation of the PFC or ACC has the potential for pain modulation.