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REVIEW article
Front. Oral. Health
Sec. Oral Infections and Microbes
Volume 6 - 2025 | doi: 10.3389/froh.2025.1571492
Animal models of oral infectious diseases
Provisionally accepted
Jing Li 1,2
Ya-Nan Zhao 1,2
Yi-Hui Wang 1,2
Yao Chen 2,3
Jia-Long Hou 2,3
Da-Yuan Wang 1,4*
Linqi Shi 4*
Jing Shen 1,2*- 1 Department of International VIP Dental Clinic, Tianjin Stomatological Hospital, Tianjin, China
- 2 Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
- 3 Department of Operative Dentistry and Endodontics, Tianjin Stomatological Hospital, Tianjin, China
- 4 State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China
Oral infectious diseases, including caries, pulpitis, periodontitis, and oral candidiasis, are caused by plaque biofilm or dysbiosis. These conditions affect over two billion people worldwide, imposing a significant burden on healthcare systems and economies. Developing suitable animal models is crucial for investigating the underlying mechanisms of these diseases and evaluating potential therapeutic strategies. Currently, most animal models of oral infectious diseases are built via inoculating a single pathogenic bacterium. However, these models often fail to fully replicate the complex disease processes observed in humans. As a result, alternative methods are needed to explore more accurate animal models that better represent the progression of oral infectious diseases. Herein, this mini-review provides a concise overview of strategies for constructing animal models of oral infectious diseases, focusing on four representative conditions: caries, pulpitis, periodontitis, and oral candidiasis. The goal is to offer valuable insights and references for researchers working in the field of animal model development for oral health.
Keywords: oral infectious disease1, animal model2, caries3, pulpitis4, periodontitis5, oral candidiasis6
Received: 08 Feb 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Li, Zhao, Wang, Chen, Hou, Wang, Shi and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Da-Yuan Wang, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China
Linqi Shi, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China
Jing Shen, Department of International VIP Dental Clinic, Tianjin Stomatological Hospital, Tianjin, 10002197, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.