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ORIGINAL RESEARCH article
Front. Oral. Health
Sec. Oral Infections and Microbes
Volume 6 - 2025 | doi: 10.3389/froh.2025.1568983
Emerging oral Treponema membrane proteins disorder neutrophil phosphoinositide signaling via Phosphatidylinositol-4-phosphate 5-kinase
Provisionally accepted- University at Buffalo, Buffalo, United States
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Background: Periodontitis (PD) is a group of inflammatory pathologies characterized by destruction of the tooth-supporting tissues. During PD, dysbiosis of the oral biofilm disrupts the host immune response and supports growth of pathogenic bacteria including the spirochetes Treponema denticola (Td), T. maltophilum (Tm), and T. lecithinolyticum (Tl). The outer membrane protein of Td, Msp, perturbs the function of neutrophils by modulating phosphoinositide (PIP) signaling. While Tm and Tl have similar outer membrane proteins, MspA and MspTL respectively, little is known of how these proteins affect neutrophil function. Methods: This study examines putative mechanisms by which T. maltophilum MspA and T. lecithinolyticum MspTL inhibit neutrophil chemotaxis.
Keywords: Periodontitis, Neutrophil, Treponema, phosphoinositide, actin itis (PD) hard tooth-supporting tissues Normal (Web), Widow/Orphan control, Adjust space between Latin and Asian text, Adjust space between Asian text and numbers Formatted: Font: Not Italic Font: Not Italic Formatted: Font: 12 pt Formatted: Font: 12 pt Font: 12 pt
Received: 31 Jan 2025; Accepted: 20 Mar 2025.
Copyright: © 2025 Anselmi, Vanyo and Visser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Michelle B Visser, University at Buffalo, Buffalo, United States
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