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ORIGINAL RESEARCH article
Front. Oral. Health
Sec. Oral Health and Nutrition
Volume 6 - 2025 | doi: 10.3389/froh.2025.1564838
Ion Release Dynamics of Bioactive Resin Cement Under Variable pH Conditions
Provisionally accepted
Venkata Suresh Venkataiah 1
Krithikadatta Jogikalmat 2*
Venkata Teja Kavalipurapu 1 Deepak Mehta 2 Mukesh Dhoble 2- 1 Saveetha Dental College And Hospitals, Chennai, Tamil Nadu, India
- 2 Department of Cariology, Saveetha Dental College And Hospitals, Chennai, Tamil Nadu, India
Introduction: Understanding the ion release behaviour of bioactive resin cements is essential for evaluating their potential in restorative dentistry. Sustained ion release, especially at cariogenic pH levels, can enhance remineralization and prolong the longevity of dental restorations. This study investigates the influence of pH on the ion release profiles of a bioactive resin cement before and after recharging.Methods: Disk-shaped specimens (n=15) of bioactive resin cement were prepared and exposed to three different pH conditions (4.5, 5.5, and 6.5) to simulate normal and cariogenic environments.Calcium ion release was quantified using atomic spectrophotometry, while fluoride and phosphate ions were analyzed using quantitative spectrophotometry. After an initial 30-day depletion phase, recharging was performed using casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) paste.In the pre-recharging phase (Stage 1), calcium ion release was more pronounced at acidic pH (4.5-5.5), particularly in the first five days. Fluoride and phosphate ions also demonstrated higher release at pH 4.5 and 5.5 compared to pH 6.5. Post-recharging (Stage 2) exhibited similar trends, emphasizing the role of regular recharge in sustaining ion availability. The absence of an initial burst release, commonly seen in other bioactive materials, suggests a distinct ion release mechanism in these resin cements.The findings highlight the pH-dependent release characteristics of bioactive resin cements and reinforce the importance of recharging for maintaining their therapeutic potential. The unique release kinetics observed may offer advantages in long-term remineralization strategies for dental restorations.
Keywords: Dental biomaterials, remineralization, ion release, Predicta Bioactive Self-adhesive Cement, PH sensitivity, CPP-ACP paste
Received: 22 Jan 2025; Accepted: 24 Feb 2025.
Copyright: © 2025 Venkataiah, Jogikalmat, Kavalipurapu, Mehta and Dhoble. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Krithikadatta Jogikalmat, Department of Cariology, Saveetha Dental College And Hospitals, Chennai, 600077, Tamil Nadu, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.