SYSTEMATIC REVIEW article
Front. Oral. Health
Sec. Oral Health Promotion
Volume 6 - 2025 | doi: 10.3389/froh.2025.1564599
Role of hyaluronic acid in the treatment of peri-implant diseases: Results of a meta-analysis
Provisionally accepted
- University of Salamanca, Salamanca, Spain
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Peri-implantitis is an infectious-inflammatory disease that affects the tissues surrounding implants and is one of the main causes of implant failure. Hyaluronic acid (HA) is a natural polymer with multiple biomedical and cosmetic applications. The aim of this systematic review and meta-analysis was to evaluate its efficacy in the treatment of peri-implant disease. Methods-In accordance with PRISMA, the question was established: is HA treatment effective as a sole or adjunctive therapy for the treatment of peri-implantitis? PubMed/Medline, Embase, Cochrane Central, Dentistry & Oral Sciences Source and Web of Science were searched until December 2024. Inclusion criteria were interventional studies (RCTs and case series), according to the PICOs strategy in subjects with periimplant pathology (participants), treated with HA (intervention) compared to conventionally treated or untreated patients (control) and assessing response to treatment (outcomes). Results-Thirty-two studies were obtained and four were selected. Risk of bias was assessed using the Cochrane Risk of Bias tool and methodological quality using the Joanna Briggs Institute tool. Meta-analysis of parameters was performed for pooled studies and for subgroups. The overall effect was in favour of the experimental group. Conclusions-The use of HA as background or adjunctive therapy in periimplantitis may be effective, although well-designed RCTs are warranted to validate the efficacy of the product.
Keywords: hyaluronic acid1, dental implants2, Peri-implantitis3, Clinical trial4, Meta-analysis5
Received: 21 Jan 2025; Accepted: 24 Apr 2025.
Copyright: © 2025 López-Valverde, López-Valverde and Blanco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Antonio López-Valverde, University of Salamanca, Salamanca, Spain
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