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REVIEW article
Front. Oral. Health
Sec. Oral Infections and Microbes
Volume 6 - 2025 | doi: 10.3389/froh.2025.1524364
This article is part of the Research Topic Diagnosis and Therapeutic Interventions for Oral Diseases View all 3 articles
Role of Transcriptomics in the study of Oral Cancer
Provisionally accepted- 1 Ajman University, Ajman, Ajman, United Arab Emirates
- 2 Thai Moogambigai Dental College and Hospital, Chennai, India
Oral cancer, a formidable public health challenge, demands innovative approaches for early detection and effective treatment. This review explores the transformative role of transcriptomics in oral cancer research, leveraging cutting-edge technologies to decode the RNA landscape of tumors. We delve into RNA sequencing (RNA-seq), single-cell RNA sequencing (scRNA-seq), long non-coding RNA sequencing (lncRNA-seq), microarray analysis, and small RNA profiling, showcasing their unique contributions to unraveling the complexities of oral cancer. By mapping gene expression patterns, identifying biomarkers, and understanding tumor heterogeneity at an unprecedented resolution, transcriptomics offers powerful insights into the molecular mechanisms driving oral cancer. Furthermore, we highlight how these approaches pave the way for personalized medicine, enabling precise therapeutic interventions and innovative treatment strategies. The review also addresses the future directions and challenges in the field, emphasizing the need for advanced computational tools and interdisciplinary collaboration to fully harness the potential of transcriptomics in transforming oral cancer care.
Keywords: oral cancer, Transcriptomics, RNA sequencing, Microarray Analysis, Small RNA profiling, biomarkers, heterogeneity, therapeutic targets
Received: 07 Nov 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Natarajan and Umapathy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dr Vidhya Rekha Umapathy, Thai Moogambigai Dental College and Hospital, Chennai, India
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