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REVIEW article
Front. Oral. Health
Sec. Oral Epidemiology
Volume 6 - 2025 | doi: 10.3389/froh.2025.1523024
This article is part of the Research TopicThe mouth as a diagnostic window: Unveiling the systemic implications of oral healthView all 3 articles
Exploring the Association of Calbindin -D28K in Renal Dialysis with Oral Health: A Comprehensive Review
Provisionally accepted- 1Ajman University, Ajman, United Arab Emirates
- 2Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, Ajman, United Arab Emirates
- 3AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India
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Background: The kidney, brain, and endocrine glands all express calbindin-D28K, a calcium-binding protein that is essential for maintaining calcium homeostasis. Calcium metabolism is disturbed in chronic kidney disease (CKD), which may have an impact on dental and bone health. Patients on dialysis frequently have changed salivary composition, which raises their risk of dental problems such tooth decay and periodontal disease. Although there is no direct study on the relationship between Calbindin-D28K and dental health in dialysis patients, its function in calcium control raises the possibility of a connection that merits more investigation. Objective: To address the impact of Calbindin-D28K levels in chronic kidney disease on oral health.Design: A comprehensive electronic search was conducted using databases like PubMed, ResearchGate, SCOPUS, and others, to find relevant articles published before May 2024. The search terms included Calbindin-D28K, renal dialysis, dental and oral health, Vitamin D, calcium, end-stage renal disease, and related topics. The review examined studies from 1975 to 2024, focusing on the relationship between dental health and renal dialysis and factors affecting Calbindin-D28K levels. Results: A total of 48 articles were retrieved through electronic database. After evaluating the title, abstract, and full text of these articles, only 7 were selected for the present review. Final consideration: Based on the data available on selected studies, they point to a possible association between these people's higher frequency of periodontal disease and tooth caries and lower levels of Calbindin-D28K.It is imperative to recognize the reciprocal impact of systemic illnesses on oral health. In addition to being important for maintaining calcium homeostasis, calbindin-D28K may also be a biomarker for renal damage and have an impact on dental health. Its relevance for both diagnosis and treatment of chronic kidney disease and associated diseases is highlighted by its involvement in renal function and neuroprotection.
Keywords: Calbindin-D28k, Renal Dialysis, Oral Health, Chronic Kidney Disease, REB
Received: 05 Nov 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Maniangat Luke, Jaber, Ingagou and Shetty. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Alexander Maniangat Luke, Ajman University, Ajman, United Arab Emirates
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.