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MINI REVIEW article

Front. Oral. Health
Sec. Oral Health and Nutrition
Volume 6 - 2025 | doi: 10.3389/froh.2025.1520067

Hypovitaminosis and Its Association with Recurrent Aphthous Stomatitis: A Comprehensive Review of Clinical Correlations and Diagnostic Considerations Mini-Review

Provisionally accepted
Alessio Rosa Alessio Rosa 1*Giovanni Cianconi Giovanni Cianconi 1Riccardo De Angelis Riccardo De Angelis 1Alberto Maria Pujia Alberto Maria Pujia 2Claudio Arcuri Claudio Arcuri 3
  • 1 Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Roma, Italy
  • 2 Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Lazio, Italy
  • 3 Dipartimento di Scienze Cliniche e Medicina Traslazionale, Università di Roma Tor Vergata, Rome, Lazio, Italy

The final, formatted version of the article will be published soon.

    The objective of this study is to explore the association between hypovitaminosis and recurrent aphthous stomatitis (RAS), with a specific focus on identifying the clinical and biochemical manifestations of vitamin deficiencies-particularly involving vitamins B12, C, and folate-in patients with RAS. This review aims to emphasize the role of hypovitaminosis as a potential contributing factor in RAS and to provide insights into the diagnostic and therapeutic implications of identifying vitamin deficiencies in affected individuals.

    Keywords: resources, Validation, visualization, Writing -original draft, Writing -review & editing. Claudio Arcuri: Project administration, supervision, Writing -review & editing. Alessio Rosa: Conceptualization, Data curation

    Received: 30 Oct 2024; Accepted: 09 Jan 2025.

    Copyright: © 2025 Rosa, Cianconi, De Angelis, Pujia and Arcuri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Alessio Rosa, Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Roma, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.