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ORIGINAL RESEARCH article

Front. Oral. Health
Sec. Oral Infections and Microbes
Volume 5 - 2024 | doi: 10.3389/froh.2024.1514070
This article is part of the Research Topic Odontogenic Infection as a Complication of Dental Caries: Microbiological and Molecular Aspects - Volume II View all articles

Forecasting the development of antimicrobial resistance of S. aureus

Provisionally accepted
Oleh Shemetov Oleh Shemetov 1Mariia Faustova Mariia Faustova 2*Tetiana Perepelova Tetiana Perepelova 1Hennadii Balia Hennadii Balia 1Ihor Pavlish Ihor Pavlish 1Galina Loban' Galina Loban' 2
  • 1 Poltava State Medical University, Poltava, Ukraine
  • 2 Microbiology, Virology and Immunology Department, Poltava State Medical University, Poltava, Ukraine

The final, formatted version of the article will be published soon.

    Today, about 15.0% of odontogenic pathology is caused by Staphylococcus aureus (S. aureus). The aim of the study was to predict the development of antimicrobial resistance of S. aureus based on retrospective data. Methods. A total of 425 patients undergoing treatment for odontogenic infectious diseases of the facial area during 2019-2023 were involved in the study. The object of the study was 106 clinical isolates of S. aureus that were isolated and identified from patients. Determining the sensitivity of the obtained isolates to antimicrobial drugs was carried out using Vitek antimicrobial susceptibility testing (Biomerioux, France) and analyzed according to the breackpoint tables of the EUCAST. Prediction of the development of antimicrobial resistance of S. aureus to various antibiotics was carried out on the basis of the received sensitivity data of the studied isolates in 2019-2023 using the exponential smoothing method.Results. The antimicrobial resistance of S. aureus isolates to various antibiotics changed annually during 2019-2023. The level of resistance of S. aureus isolates to benzylpenicillin wavered between 40-50% from 2019 to 2023 with the trend of an 18.0% increase over the next five years. A uniform plateau of antimicrobial resistance of S. aureus to cefoxitin is predicted at the level of 32.0% during 2024-2028. We recorded the highest portions of S. aureus resistant to norfloxacin (33.3%) and ciprofloxacin (16.7%) in 2023 with prediction of its increasing in the next five years within the range of 20.0%. It was established that S. aureus may reach 100.0% resistance to gentamicin in 2027. According to exponential smoothing, the level of S. aureus resistance to amikacin will increase by 22.7% over the next five-year period. Moreover, representatives of this species of bacteria can develop complete (100.0%) resistance to tetracycline as early as 2027.Conclusions. Mathematical prediction of the development of antimicrobial sensitivity of S. aureus isolates showed a high probability of its development to antibiotics of all groups in the next five years.

    Keywords: antimicrobial resistance 1, S. aureus 2, antibiotics3, odontogenic infections4, phlegmons5, forecasting6

    Received: 19 Oct 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 Shemetov, Faustova, Perepelova, Balia, Pavlish and Loban'. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mariia Faustova, Microbiology, Virology and Immunology Department, Poltava State Medical University, Poltava, Ukraine

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