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EDITORIAL article

Front. Oral. Health
Sec. Oral Cancers
Volume 5 - 2024 | doi: 10.3389/froh.2024.1507867
This article is part of the Research Topic Insights in Oral Cancers: 2023 View all 11 articles

Editorial: Insights in Oral Cancers: 2023

Provisionally accepted
Ricardo D. Coletta Ricardo D. Coletta 1*Ali-Farid Safi Ali-Farid Safi 2Arnab Pal Arnab Pal 3Rogelio González-González Rogelio González-González 4
  • 1 Department of Oral Diagnosis, School of Dentistry of Piracicaba, Campinas State University, Piracicaba, Brazil
  • 2 Faculty of Medicine, University of Berne, and Craniologicum, Center for Craniomaxillofacial Surgery, Berne, Switzerland
  • 3 Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • 4 Research Department, School of Dentistry. Juarez University of the State of Durango, Durango, Mexico

The final, formatted version of the article will be published soon.

    of epithelial dysplasia) features have been related to malignant transformation (5,6), it is still difficult to forecast which OL will progress to oral cancer. Based on a systematic review and meta-analysis, Normando et al. performed an in-depth analysis of various potential protein biomarkers for malignant transformation of OL. From a total of 173 distinct proteins, 18 proteins were subjected to quantitative assessment with metaanalysis, and 8 of them, including pRb, cadherin-1, mdm2, PD-L1, mucin-4, periostin and cytokeratins 13 and 19, showed statistically different levels between OL and OSCC, suggesting that may be related to increased risk of OL malignant transformation. Anaya-Saavedra and Vázquez-Garduño review the many faces of the oral human papillomavirus (HPV)-associated dysplasia, from clinical and pathological features to the prognosis and progression risk. Although described originally in 1986, only in recent years it has gained more attention due to the HPV role in oral carcinogenesis. The authors emphasize the importance of the accurate diagnosis, particularly among highrisk patients, to facilitate early intervention and offer a critical advantage in its management.The complex crosstalk between tumor cells and the components of the microenvironment may carry out both pro-and anti-tumor activities in both early and advanced stages of the oral cancer (7)

    Keywords: oral cancer, diagnosis, Treatment, prognosis, Cancer stem cell, Oral potentially malignant disorders (OPMD), systematic review

    Received: 08 Oct 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Coletta, Safi, Pal and González-González. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ricardo D. Coletta, Department of Oral Diagnosis, School of Dentistry of Piracicaba, Campinas State University, Piracicaba, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.