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ORIGINAL RESEARCH article

Front. Oral. Health
Sec. Preventive Dentistry
Volume 5 - 2024 | doi: 10.3389/froh.2024.1506616

Effect of a Chemically-Modified-Curcumin on Dental Resin Biodegradation

Provisionally accepted
Qi Dai Qi Dai *HSIMING LEE HSIMING LEE Austin Giordano Austin Giordano Fu-Pen Chiang Fu-Pen Chiang Stephen Walker Stephen Walker Rafael Delgado Ruiz Rafael Delgado Ruiz Francis Johnson Francis Johnson Lorne M Golub Lorne M Golub Ying Gu Ying Gu
  • Stony Brook University, Stony Brook, United States

The final, formatted version of the article will be published soon.

    Introduction: Previous studies have shown Streptococcus mutans (S. mutans) esterase is a key mediator of dental composite biodegradation, which can contribute to recurrent caries. This study is to investigate the inhibitory effects of a novel Chemically-Modified-Curcumin (CMC 2.24) on esterase activities and related dental material biodegradation.Methods: Dental adhesive materials and composite resins were incubated in S. mutans suspension with CMC 2.24 and other compounds, including doxycycline, Chemically-Modified-Tetracycline (CMT-3), and curcumin for 4 weeks. The pre-and post-incubation surface roughness were evaluated by either laser diffraction pattern and/or a 3D laser scanning microscope. Esterase enzyme inhibition assays were performed with the same test groups and activities were determined spectrophotometrically.Results: Among all experimental groups, CMC 2.24 significantly reduced surface roughness of dental composite (p<0.01) and adhesive (p<0.01) materials compared to bacteria-only group.Additionally, CMC 2.24 reduced porcine esterase activity by 46.5%, while other compounds showed minimal inhibition. In the S. mutans esterase assay, CMC 2.24 showed inhibition of 70.0%, while other compounds showed inhibition ranging from 19% to 36%.Our study demonstrated that CMC 2.24 inhibited biodegradation of dental composite material more effectively than its mother compound, curcumin. Moreover, the mechanism of this biodegradation was likely mediated through bacterial esterase activity. Doxycycline achieved similar inhibition by completely eradicating S. mutans with its antibiotic action; hence, it is not recommended for long-term use.

    Keywords: Dental Caries, Dental cavities, Dental Caries Susceptibility, Fluoride, Streptococcus mutans, Doxycycline

    Received: 05 Oct 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Dai, LEE, Giordano, Chiang, Walker, Delgado Ruiz, Johnson, Golub and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qi Dai, Stony Brook University, Stony Brook, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.