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SYSTEMATIC REVIEW article

Front. Oral. Health
Sec. Cardiometabolic Health
Volume 5 - 2024 | doi: 10.3389/froh.2024.1473744
This article is part of the Research Topic Periodontitis and Cardiovascular Disease: Shared Clinical Challenges in Patient Care View all 3 articles

Impact of Cerebrovascular Stroke on Inflammatory Periodontal Indices: A Systematic Review with Meta-analysis and Trial Sequential Analysis of Case-control Studies

Provisionally accepted
Mario Dioguardi Mario Dioguardi 1Maria E. Bizzoca Maria E. Bizzoca 1Stefania Cantore Stefania Cantore 2*Giorgia A. Caloro Giorgia A. Caloro 3Gennaro Musella Gennaro Musella 1Filiberto Mastrangelo Filiberto Mastrangelo 1Lorenzo Lo Muzio Lorenzo Lo Muzio 1Andrea Ballini Andrea Ballini 1
  • 1 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Apulia, Italy
  • 2 Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Campania, Italy
  • 3 1. Unità Operativa Nefrologia e Dialisi, Presidio Ospedaliero Scorrano, ASL (Azienda Sanitaria Locale) Lecce, Via Giuseppina Delli Ponti, 73020, Scorrano, Italy; (G.A.C.), lecce, Italy

The final, formatted version of the article will be published soon.

    Introduction: Cerebrovascular stroke, a leading cause of global morbidity and mortality, is influenced by several modifiable risk factors such as hypertension, diabetes, and smoking. Emerging evidence highlights the significant role of inflammation in stroke pathogenesis, with conditions like periodontitis potentially exacerbating this risk. The aim of this systematic review was to identify and quantify the real impact of periodontal disease in individuals with cerebral stroke through the analysis of inflammatory periodontal indices Methods: Following PRISMA guidelines, we conducted a systematic review and meta-analysis of casecontrol studies assessing periodontal indices in stroke patients. Data sources included PubMed, Scopus, and Cochrane Library, with searches extended to grey literature. The review protocol was registered on PROSPERO (CRD42024529767). Studies were evaluated using the Newcastle-Ottawa Scale to assess risk of bias, and meta-analyses were conducted using Review Manager 5.4 and TSA software.The review included seven case-control studies, comprising 723 stroke patients and 787 controls.Meta-analyses revealed significant differences between stroke and control groups in clinical attachment loss (MD 1.04 mm, 95% CI [0.54, 1.54]), probing pocket depth (MD 0.68 mm, 95% CI [0.31, 10.6]), and radiological bone loss (MD 2.15 mm, 95% CI [-1.58, 5.89]. These findings indicate that stroke patients exhibit worse periodontal health compared to controls, supporting a potential link between periodontal inflammation and stroke.This study confirms the significant impact of periodontal disease on stroke patients and highlights the importance of oral health in preventing adverse cerebrovascular events.

    Keywords: Stroke, Periodontal, Periodontitis, Brain, Oral and dental health, bone loss, oral inflammation, risk factor, Tooth Loss

    Received: 31 Jul 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Dioguardi, Bizzoca, Cantore, Caloro, Musella, Mastrangelo, Lo Muzio and Ballini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Stefania Cantore, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, 80138, Campania, Italy

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