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SYSTEMATIC REVIEW article

Front. Oral. Health
Sec. Oral Health Promotion
Volume 5 - 2024 | doi: 10.3389/froh.2024.1441601

Drug assumption and awareness about adverse drug reactions. The right to know. The case of the Bone-Modyfing Agents: a systematic review

Provisionally accepted
Rodolfo Mauceri Rodolfo Mauceri 1Sonia Arduini Sonia Arduini 2Martina Coppini Martina Coppini 1*Monica Bazzano Monica Bazzano 1Isabel Trujillo Isabel Trujillo 2Giuseppina Campisi Giuseppina Campisi 3
  • 1 Department of Medicine of Precision in the Medical, Surgical and Critical Care Areas, University of Palermo, Palermo, Italy
  • 2 Department of Law, University of Palermo,Italy, Palermo, Italy
  • 3 University of Palermo, Palermo, Sicily, Italy

The final, formatted version of the article will be published soon.

    Medication-related osteonecrosis of the Jaw (MRONJ) is an adverse drug reaction that affects the mandible and maxilla of patients exposed to BMA and AA therapies, causing the progressive destruction and death of bone. To date, oral health preventive measures remain the most effective strategy to reduce MRONJ incidence, and, in this sense, the major goal is to diagnose, treat, and eradicate any oral diseases that could compromise oral health. The present systematic review aims to investigate the awareness of MRONJ among patients assuming BMAs. A systematic literature search was performed, selecting studies that concern the awareness of patients of the risk of MRONJ. Six studies were included in this review. In total, 483 patients were evaluated. Of the 483 included patients, 391 were not aware of the possibility of MRONJ onset (391/483, 81%) and 92 were aware of it (92/483, 19%). The problem of patient's lack of awareness with respect to MRONJ risk presents different layers of complexity ("what?", "who?", "where?", "when?" and "why?"). Among its causal factors, there are an inadequate level of communication with patients and the lack of collaboration between healthcare professionals, which is related to an individualistic view of liability and deontological duties. MRONJ is a drug adverse reaction that can greatly affect the quality of life of patients if not promptly diagnosed and treated. Therefore, patients must be fully aware of the risks of adverse and the importance of preventive measures, which imply effective and exhaustive communication by each member of the multidisciplinary team. Effective teamwork and collaborative care should be promoted to positively impact patients' awareness.

    Keywords: Awareness, knowledge, Patients, Bisphosphonate-Associated Osteonecrosis of the Jaw, osteonecrosis of the jaw, Medication-related osteonecrosis of the jaw, MRONJ, ONJ

    Received: 03 Jul 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Mauceri, Arduini, Coppini, Bazzano, Trujillo and Campisi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Martina Coppini, Department of Medicine of Precision in the Medical, Surgical and Critical Care Areas, University of Palermo, Palermo, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.