AUTHOR=Malcolm Jennifer , Culshaw Shauna 

TITLE=Aberrant immunity in the oral cavity—a link with rheumatoid arthritis?

JOURNAL=Frontiers in Oral Health

VOLUME=5

YEAR=2024

URL=https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2024.1430886

DOI=10.3389/froh.2024.1430886

ISSN=2673-4842

ABSTRACT=<p>There are well established epidemiological links between rheumatoid arthritis and periodontitis. Recent data have started to shed light on the mechanisms that might underlie the relationship between these two complex diseases. Unravelling the roles of distinct pathways involved in these mechanisms has the potential to yield novel preventative and therapeutic strategies for both diseases. Perhaps most intriguingly, this represents an area where understanding the biology in the oral cavity might reveal fundamental advances in understanding immune regulation and the relationships between the host and microbiome. Here we seek to discuss aspects of the adaptive immune response that might link periodontitis and rheumatoid arthritis.</p>