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SYSTEMATIC REVIEW article

Front. Oral. Health
Sec. Oral and Maxillofacial Surgery
Volume 5 - 2024 | doi: 10.3389/froh.2024.1360298

Efficacy of Submucosal Administration of Tramadol on Acute Pain Following Third Molar Surgery: A Systematic Review and Meta-Analysis

Provisionally accepted
Ahamd Assari Ahamd Assari 1*Elaf Algharbi Elaf Algharbi 2Abdulmajeed Abuhabsha Abdulmajeed Abuhabsha 3Basel Alshammry Basel Alshammry 4Yosef Alanazi Yosef Alanazi 4Reem Abuhaimed Reem Abuhaimed 3Ali Alzahrani Ali Alzahrani 5Abdulrahaman Alduhaim Abdulrahaman Alduhaim 4
  • 1 Riyadh Elm University, Riyadh, Saudi Arabia
  • 2 King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  • 3 King Saud University, Riyadh, Riyadh, Saudi Arabia
  • 4 University of Hail, Ha'il, Hail, Saudi Arabia
  • 5 Ministry of Health (Saudi Arabia), Riyadh, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    Objectives: This systematic review aimed to assess the effectiveness of submucosal tramadol injections in post-operative pain management following third molar surgical extraction.Databases, such as PubMed, Scopus, ScienceDirect, and Cochrane Library, were systematically searched using relevant keywords. Randomized clinical trials that met the inclusion criteria were assessed to determine the effectiveness of tramadol in managing acute post-operative pain following third molar surgery.In total, seven studies with participants of 18 and over following randomized placebocontrolled trials were considered for the analysis. A submucosal injection of 2 mL (50-100 mg) of tramadol adjacent to the impacted mandibular third molar effectively controlled pain for up to 6-24 hours following surgery. Non-serious adverse events, such as nausea, vomiting, and headache, were reported in two studies. Meta-analysis (subgroup analysis) revealed heterogeneity among the studies, demonstrating variability in the results across the included studies. In addition, tramadol demonstrated a significant decrease in post-operative pain.Submucosal tramadol is an efficient, safe, and dependable method for reducing post-operative acute pain, particularly in the first 6 h following impacted third molar surgery. However, due to the observed heterogeneity in the research, there is need for cautious interpretation of the findings and potential limitations in the evidence base. To enhance the quality of evidence on this topic, we strongly recommend conducting new RCTs using established methodologies.Clinical Relevance: Post operative pain following third molar surgeries is one of the common complications. Submucosal tramadol injections were found to be successful in reducing post extraction pain as well as other morbidities.

    Keywords: Numbering: Continuous Deleted: Injection analgesic, post-operative pain, Opioids, impacted teeth, randomized clinical trial Font: (Default) Times New Roman, 12 pt, Complex Script Font: Times New Roman, 12 pt Font: (Default) Times New Roman

    Received: 22 Dec 2023; Accepted: 28 Oct 2024.

    Copyright: © 2024 Assari, Algharbi, Abuhabsha, Alshammry, Alanazi, Abuhaimed, Alzahrani and Alduhaim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ahamd Assari, Riyadh Elm University, Riyadh, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.