AUTHOR=Varma Sudhir , Thomas Biju , Subrahmanyam K. , Duarte Kimberly , Alsaegh Mohammed A. , Gopinath Divya , Kuriadom Sam T. , Narayanan Jayaraj , Desai Vijay B. , Khair Al Moutassem B. , Afrashtehfar Kelvin I. 

TITLE=Salivary levels of inflammatory and anti-inflammatory biomarkers in periodontitis patients with and without acute myocardial infarction: implications for cardiovascular risk assessment

JOURNAL=Frontiers in Oral Health

VOLUME=Volume 5 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2024.1332980

DOI=10.3389/froh.2024.1332980

ISSN=2673-4842

ABSTRACT=Background:  Macrophage inflammatory protein-1 alpha (MIP-1α) and C-reactive protein (CRP) are pro- inflammatory biomarkers that quantify clinical and subclinical inflammation in cardiac ischemia in cardiac inflammation and disease. Adiponectin is an anti-inflammatory marker associated with good health and more specifically to cardiovascular health. The susceptibility of periodontitis patients to cardiovascular events needs to be evaluated.
Objective: This study aims to assess the levels of biomarkers in periodontitis patients with and without acute myocardial infarction (AMI) compared to controls. Material and methods: Pro-inflammatory and anti-inflammatory analytes were examined by collecting unstimulated saliva from three groups (n = 20/each): healthy individuals, individuals with stage III periodontitis, and post-myocardial infarction patients with stage III periodontitis. The samples were collected within 48 hours of AMI. Results: Adiponectin levels were significantly lower in patients with periodontitis with and without AMI compared to controls, while CRP and MIP-1α were significantly higher in patients with periodontitis with and without AMI compared to controls. The highest titers for MIP-1α and CRP were detected among patients with periodontitis and AMI. Conclusion: Our study provides possible evidence of the association between periodontitis and salivary analytes that occur in tandem with cardiovascular disease. The lower levels of Adiponectin and higher levels of CRP and MIP-1α in patients with periodontitis indicate that this condition is a potential risk factor for cardiovascular disease. The findings demonstrate the activity of pro-inflammatory markers in both periodontitis and cardiovascular events.