AUTHOR=Ozuna Hazel , Snider Ian , Belibasakis Georgios N. , Oscarsson Jan , Johansson Anders , Uriarte Silvia M. 

TITLE=Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens

JOURNAL=Frontiers in Oral Health

VOLUME=3

YEAR=2022

URL=https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2022.981343

DOI=10.3389/froh.2022.981343

ISSN=2673-4842

ABSTRACT=<p>Periodontitis is a dysbiotic disease caused by the interplay between the microbial ecosystem present in the disease with the dysregulated host immune response. The disease-associated microbial community is formed by the presence of established oral pathogens like <italic>Aggregatibacter actinomycetemcomitans</italic> as well as by newly dominant species like <italic>Filifactor alocis</italic>. These two oral pathogens prevail and grow within the periodontal pocket which highlights their ability to evade the host immune response. This review focuses on the virulence factors and potential pathogenicity of both oral pathogens in periodontitis, accentuating the recent description of <italic>F. alocis</italic> virulence factors, including the presence of an exotoxin, and comparing them with the defined factors associated with <italic>A. actinomycetemcomitans</italic>. In the disease setting, possible synergistic and/or mutualistic interactions among both oral pathogens might contribute to disease progression.</p>