AUTHOR=Pedroso Caique Mariano , Migliorati Cesar Augusto , Epstein Joel B. , Ribeiro Ana Carolina Prado , Brandão Thaís Bianca , Lopes Márcio Ajudarte , de Goes Mário Fernando , Santos-Silva Alan Roger TITLE=Over 300 Radiation Caries Papers: Reflections From the Rearview Mirror JOURNAL=Frontiers in Oral Health VOLUME=3 YEAR=2022 URL=https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2022.961594 DOI=10.3389/froh.2022.961594 ISSN=2673-4842 ABSTRACT=

Radiation caries (RC) is an aggressive oral toxicity in head and neck cancer survivors, which develops 6 to 12 months after head and neck radiotherapy. It initially affects the tooth cervical/incisal surfaces, and if not promptly diagnosed/managed, progresses to dental crown amputation and risk of osteoradionecrosis. It results from a multidimensional cluster of treatment-induced oral symptoms, including hyposalivation, dietary changes, and oral hygiene impairment. Although recognized as a frequent complication of radiotherapy and extensively assessed by a myriad of retrospective, in vitro, and in situ studies, RC patients are still orphans of clinically validated methods for risk prediction, prevention, and treatment of early lesions. This review provides a historical overview of science-based concepts regarding RC pathogenesis and treatment, emphasizing the growing demand for interventional clinical studies (randomized trials).