Correlation between lens diameter and ocular biological parameters based on CASAI2

Fan Li¹Ling Chen¹Jinjun Tie²Li Tang^2*

• ¹School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China
• ²Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China

To explore the characteristics of lens diameter (LD) by CASIA2 in different scanning axes and its relationship with ocular biological parameters.Methods: A total 180 subjects one eye from each patient was scanned (total 180 eyes). The LD in 16 axial directions were obtained through radial scanning of 16 images by CASIA2, pseudo-three-dimensional LD (P3D-LD) were created based on the acquisition of 16 cross-sectional images. The ocular biological parameters were measured through IOL-Master700, including white-to-white (WTW), anterior chamber depth (ACD), and lens thickness (LT). The correlation between P3D-LD and ocular biological parameters was analyzed. The contribution of age and ocular parameters to P3D-LD was analyzed by multiple regression method. The difference of maximum LD and minimum LD in horizontal, oblique -axis and vertical groups were compared. The distribution of LD in three groups was analyzed.Results: P3D-LD was 9.73(8.83,10.36)mm, There was no significant difference in P3D-LD between men and women(Z=-0.335, P=0.738). Correlation analysis showed that P3D-LD was positively correlated with age (rs=0.217, P<0.05), LT (rs=0.538, P<0.001). It was negatively correlated with ACD (rs=-0.379, P<0.001). Multiple linear regression with age, WTW, LT, ACD, and AL as independent variables yielded an adjusted R2=0.334, in which LT(standardized β=0.483) and AL(standardized β=0.314, P < 0.001) could significantly affect the P3D-LD. A significant difference of LD between the maximum and the minimum was observed (Z=-7.387). There was no significant difference in the maximum LD(Z=0.927, P= 0.629) or the minimum LD((Z=0.927, P= 0.629) among horizontal, oblique -axis and vertical groups. There were statistically significant differences in the distribution of the maximum or minimum LD among the three groups(χ 2 =7.040， P=0.03). After pairwise comparison, it was a substantial difference between the maximum LD distribution and the minimum LD distribution in the horizontal group.The lens is not a regular circle. In this study group, the minimum LD distribution was more likely in the horizontal axis group. IOL implantation in the horizontal axis will be more stable in the capsule. Current biometric parameters remain limited in predicting lens equatorial diameter. Therefore, the preferred approach remains the precise measurement of lens diameter using advanced imaging modalities to guide personalized surgical planning.