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CASE REPORT article

Front. Ophthalmol.
Sec. Retina
Volume 5 - 2025 | doi: 10.3389/fopht.2025.1557294
This article is part of the Research Topic Ischemic retinopathy: underlying pathologic mechanisms and identifying therapeutic molecular targets View all articles

Case Report: Two cases of multiple evanescent white dot syndrome with transient night blindness

Provisionally accepted
Kanna Miyake Kanna Miyake Mariko Egawa Mariko Egawa *Yoshinori Mitamura Yoshinori Mitamura Ryoji Yanai Ryoji Yanai
  • Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

The final, formatted version of the article will be published soon.

    Introduction: This study aimed to report two cases of multiple evanescent white dot syndrome (MEWDS) with transient night blindness.Case Presentation: Case 1: A 24-year-old man presented with acute visual loss and night blindness in his right eye. Examination revealed an enlarged blind spot and multiple white dots extending from the posterior pole to the peripheral retina in the right eye. Optical coherence tomography (OCT) revealed multiple disruptions of the ellipsoid zone (EZ). Full-field electroretinography (ffERG) demonstrated a more pronounced reduction in rod amplitude compared with cone amplitude in both eyes. After 3 months, the white dots, EZ disruption, and night blindness resolved spontaneously, and the ffERG amplitude normalized in the right eye. However, the enlarged blind spot persisted.Case 2: A 66-year-old woman presented with acute visual deterioration and night blindness in her right eye. The right eye exhibited an enlarged blind spot and numerous white spots widely extending from the posterior pole to the periphery. OCT revealed widespread EZ loss, and ffERG showed reduced rod and cone responses. SubTenon's triamcinolone acetonide injection was administered, and 3 months after the injection, the night blindness, ffERG abnormalities, and EZ loss had resolved, but the enlarged blind spot remained.MEWDS rarely causes transient night blindness due to extensive rod dysfunction. However, outer retinal layer damage is reversible, with night blindness typically resolving within a few months.

    Keywords: Electroretinography, Multifocal electroretinography, Multiple evanescent white dot syndrome, Optical Coherence Tomography, transient night blindness

    Received: 08 Jan 2025; Accepted: 30 Jan 2025.

    Copyright: © 2025 Miyake, Egawa, Mitamura and Yanai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mariko Egawa, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

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