SYSTEMATIC REVIEW article
Front. Ophthalmol.
Sec. Neuro-Ophthalmology Disorders
Volume 5 - 2025 | doi: 10.3389/fopht.2025.1543222
This article is part of the Research TopicOptic Neuropathies: Etiologies, Diagnosis, and TreatmentsView all articles
Effectiveness of Steroid Injection and Intravenous Immunoglobulin Therapy in Peripheral Neuropathy: A Literature Review
Provisionally accepted
Imada Khoironi1*
Rahmanita Afina Arsaputri2Muhammad falah ghani Nuruddin3
R. Mohamad Javier4
Muhamad Zulfikar Hadiaturahman5magistra manalu6- 1Faculty of Medicine, Sultan Agung Islamic University, Semarang, Central Java, Indonesia
- 2Fakultas Kedokteran, Universitas Jenderal Achmad Yani, Cimahi, West Java, Indonesia
- 3Islamic University of Indonesia, Yogyakarta, Special Region of Yogyakarta, Indonesia
- 4RSUPN Dr. Cipto Mangunkusumo, Jakarta, Jakarta, Indonesia
- 5Faculty of Medicine, Christian University of Indonesia, Jakarta, Jakarta, Indonesia
- 6Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Jakarta, Indonesia
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Optic neuritis, or inflammation of the optic nerve, is a common cause of acute optic nerve injury in both children and adults. There are various causes of optic nerve inflammation, including autoimmunity, infection, granulomatous disease, paraneoplastic syndromes, and demyelination. Optic neuritis (both demyelinating and non-demyelinating) with inflammation as the underlying cause of injury is treated with steroids due to their anti-inflammatory properties. The administration of intravenous immunoglobulin, such as sulfonated immunoglobulin G (IgG), provides anti-inflammatory and neuroprotective effects in cases of optic neuritis.This study employs a literature review methodology, utilizing a list of relevant keywords and subheadings to conduct a comprehensive search of articles evaluated in two computerized databases: PubMed and Google Scholar. The research articles included clinical trials or randomized controlled trials. All identified research articles were evaluated based on their titles and abstracts, and selected according to inclusion and exclusion criteria. This review examines six studies that demonstrate the effectiveness of steroid injections compared to intravenous immunoglobulin injections in patients with neuritis.The prognosis and treatment of optic neuritis vary, depending on the underlying cause, duration, and severity of the condition. Optimal care requires prompt diagnosis, effective treatment, and the use of intravenous corticosteroids.
Keywords: Optic Neuritis, Intravenous corticosteroids, immunoglobulin, Acute demyelinating optic neuritis, Multiple Sclerosis
Received: 11 Dec 2024; Accepted: 26 Feb 2025.
Copyright: © 2025 Khoironi, Arsaputri, ghani Nuruddin, Javier, Zulfikar Hadiaturahman and manalu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Imada Khoironi, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Central Java, Indonesia
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